Resistance to ceftriaxone and penicillin G among contemporary syphilis strains confirmed by natural in vitro mutagenesis

Abstract Background For many years, syphilis treatment was considered straightforward due to the universal susceptibility of Treponema pallidum subsp. pallidum (TPA) to penicillin antibiotics. Methods Penicillin-binding protein genes from a ceftriaxone treatment failure T. pallidum isolate were asse...

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Bibliographic Details
Main Authors: Petra Pospíšilová, Juraj Bosák, Matěj Hrala, Lenka Krbková, Eliška Vrbová, David Šmajs
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00948-x
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