Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis
Background: Chronic schistosomiasis can lead to significant morbidity. Serology is highly sensitive; however, its role in assessing treatment response is controversial. This study aimed to analyze serological values following treatment of chronic imported schistosomiasis. Methods: A retrospective ob...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/10/1/22 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587389955997696 |
|---|---|
| author | Marta González-Sanz Irene Martín-Rubio Oihane Martín Alfonso Muriel Sagrario de la Fuente-Hernanz Clara Crespillo-Andújar Sandra Chamorro-Tojeiro Begoña Monge-Maíllo Francesca F. Norman José A. Pérez-Molina |
| author_facet | Marta González-Sanz Irene Martín-Rubio Oihane Martín Alfonso Muriel Sagrario de la Fuente-Hernanz Clara Crespillo-Andújar Sandra Chamorro-Tojeiro Begoña Monge-Maíllo Francesca F. Norman José A. Pérez-Molina |
| author_sort | Marta González-Sanz |
| collection | DOAJ |
| description | Background: Chronic schistosomiasis can lead to significant morbidity. Serology is highly sensitive; however, its role in assessing treatment response is controversial. This study aimed to analyze serological values following treatment of chronic imported schistosomiasis. Methods: A retrospective observational study was performed including patients treated for chronic imported schistosomiasis from 2018 to 2022 who had at least one serological result at baseline and during follow-up. Demographic, clinical, and laboratory data were evaluated. Generalized estimating equation (GEE) models and Kaplan–Meier curves were used to analyze the evolution of serological values. Results: Of the 83 patients included, 72 (86.7%) were male, and the median age was 26 years (IQR 22–83). Most patients, 76 (91.6%), were migrants from sub-Saharan Africa. While 24 cases (28.9%) presented with urinary symptoms, the majority (59; 71.1%) were asymptomatic. <i>Schistosoma haematobium</i> eggs were observed in five cases (6.2%). Eosinophilia was present in 34 participants (40.9%). All patients had an initial positive <i>Schistosoma</i> ELISA serology, median ODI 2.3 (IQR 1.5–4.4); the indirect hemagglutination (IHA) test was positive/indeterminate in 34 cases (43.1%). Following treatment with praziquantel, serology values significantly decreased: −0.04 (IC95% −0.073, −0.0021) and −5.73 (IC95% −9.92, −1.53) units per month for ELISA and IHA, respectively. A quarter of patients (25%) had negative ELISA results 63 weeks after treatment. All symptomatic cases were clinically cured. Conclusions: Serial serological determinations could be helpful for monitoring chronic schistosomiasis in non-endemic regions. The ideal timing for these follow-up tests is yet to be determined. Further research is needed to determine the factors that influence a negative result during follow-up. |
| format | Article |
| id | doaj-art-d1c28feb6a8f473897025ab4c837b21a |
| institution | Kabale University |
| issn | 2414-6366 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj-art-d1c28feb6a8f473897025ab4c837b21a2025-01-24T13:51:24ZengMDPI AGTropical Medicine and Infectious Disease2414-63662025-01-011012210.3390/tropicalmed10010022Description of the Serological Response After Treatment of Chronic Imported SchistosomiasisMarta González-Sanz0Irene Martín-Rubio1Oihane Martín2Alfonso Muriel3Sagrario de la Fuente-Hernanz4Clara Crespillo-Andújar5Sandra Chamorro-Tojeiro6Begoña Monge-Maíllo7Francesca F. Norman8José A. Pérez-Molina9National Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainNational Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainCIBERINFEC, Instituto de Salud Carlos III, 28029 Madrid, SpainDepartamento de Medicina y Especialidades Médicas, Programa de Ciencias de la Salud, Universidad de Alcalá, 28801 Alcalá de Henares, SpainNational Reference Centre for Imported Tropical Diseases, Microbiology Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainNational Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainNational Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainNational Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainNational Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainNational Reference Centre for Imported Tropical Diseases, Infectious Diseases Department, Hospital Universitario Ramón y Cajal, IRYCIS, 28034 Madrid, SpainBackground: Chronic schistosomiasis can lead to significant morbidity. Serology is highly sensitive; however, its role in assessing treatment response is controversial. This study aimed to analyze serological values following treatment of chronic imported schistosomiasis. Methods: A retrospective observational study was performed including patients treated for chronic imported schistosomiasis from 2018 to 2022 who had at least one serological result at baseline and during follow-up. Demographic, clinical, and laboratory data were evaluated. Generalized estimating equation (GEE) models and Kaplan–Meier curves were used to analyze the evolution of serological values. Results: Of the 83 patients included, 72 (86.7%) were male, and the median age was 26 years (IQR 22–83). Most patients, 76 (91.6%), were migrants from sub-Saharan Africa. While 24 cases (28.9%) presented with urinary symptoms, the majority (59; 71.1%) were asymptomatic. <i>Schistosoma haematobium</i> eggs were observed in five cases (6.2%). Eosinophilia was present in 34 participants (40.9%). All patients had an initial positive <i>Schistosoma</i> ELISA serology, median ODI 2.3 (IQR 1.5–4.4); the indirect hemagglutination (IHA) test was positive/indeterminate in 34 cases (43.1%). Following treatment with praziquantel, serology values significantly decreased: −0.04 (IC95% −0.073, −0.0021) and −5.73 (IC95% −9.92, −1.53) units per month for ELISA and IHA, respectively. A quarter of patients (25%) had negative ELISA results 63 weeks after treatment. All symptomatic cases were clinically cured. Conclusions: Serial serological determinations could be helpful for monitoring chronic schistosomiasis in non-endemic regions. The ideal timing for these follow-up tests is yet to be determined. Further research is needed to determine the factors that influence a negative result during follow-up.https://www.mdpi.com/2414-6366/10/1/22schistosomiasismigrant healthneglected tropical diseasesdiagnosisserologytravelers |
| spellingShingle | Marta González-Sanz Irene Martín-Rubio Oihane Martín Alfonso Muriel Sagrario de la Fuente-Hernanz Clara Crespillo-Andújar Sandra Chamorro-Tojeiro Begoña Monge-Maíllo Francesca F. Norman José A. Pérez-Molina Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis Tropical Medicine and Infectious Disease schistosomiasis migrant health neglected tropical diseases diagnosis serology travelers |
| title | Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis |
| title_full | Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis |
| title_fullStr | Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis |
| title_full_unstemmed | Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis |
| title_short | Description of the Serological Response After Treatment of Chronic Imported Schistosomiasis |
| title_sort | description of the serological response after treatment of chronic imported schistosomiasis |
| topic | schistosomiasis migrant health neglected tropical diseases diagnosis serology travelers |
| url | https://www.mdpi.com/2414-6366/10/1/22 |
| work_keys_str_mv | AT martagonzalezsanz descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT irenemartinrubio descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT oihanemartin descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT alfonsomuriel descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT sagrariodelafuentehernanz descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT claracrespilloandujar descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT sandrachamorrotojeiro descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT begonamongemaillo descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT francescafnorman descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis AT joseaperezmolina descriptionoftheserologicalresponseaftertreatmentofchronicimportedschistosomiasis |