PARP1-NFATc1-PD1 pathway of maturation and stability of CD8+T cells is beneficial against chronic Trypanosoma cruzi infection
Summary: Poly(ADP-ribose) polymerase 1 (PARP1) inhibition improved the ventricular function in Chagas disease (CD). Here, we uncovered that Parp1 depletion enhances cardiac health by regulating CD8+T cell response against Trypanosoma cruzi (Tc) infection. For this, Parp1−/− and wild-type (WT) mice w...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225011873 |
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