The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study
Objective. There is a lack of information about the genotype frequencies of IL-6 −174G/C and −572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the association of the IL-6 −174G/C and −572G/C polymorphisms in Mexican mestizo with RA. Me...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/959084 |
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| author | S. A. Zavaleta-Muñiz B. T. Martín-Márquez L. Gonzalez-Lopez N. G. Gonzalez-Montoya M. L. Díaz-Toscano J. M. Ponce-Guarneros A. J. Ruiz-Padilla M. Vázquez-Del Mercado M. Maldonado-González M. Fafutis-Morris S. E. Flores-Martínez E. A. Martínez-García J. I. Gamez-Nava |
| author_facet | S. A. Zavaleta-Muñiz B. T. Martín-Márquez L. Gonzalez-Lopez N. G. Gonzalez-Montoya M. L. Díaz-Toscano J. M. Ponce-Guarneros A. J. Ruiz-Padilla M. Vázquez-Del Mercado M. Maldonado-González M. Fafutis-Morris S. E. Flores-Martínez E. A. Martínez-García J. I. Gamez-Nava |
| author_sort | S. A. Zavaleta-Muñiz |
| collection | DOAJ |
| description | Objective. There is a lack of information about the genotype frequencies of IL-6 −174G/C and −572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the association of the IL-6 −174G/C and −572G/C polymorphisms in Mexican mestizo with RA. Methods. We included 137 patients with RA and 102 healthy controls. Patients were assessed for clinical characteristics. IL-6 −174G/C and −572G/C polymorphisms were genotyped using PCR-RFLP analysis. Allele and genotype frequencies and the Hardy-Weinberg equilibrium were computed. Odds ratios (ORs) were computed to identify the risk for RA associated with the presence of GG genotype in comparison with the GC or CC genotypes. Results. The genotype −174GG occurred at a higher frequency in cases and controls (77.4% versus 78.4%, P=0.845). We found similar results for the genotype −572GG (54% in patients versus 60.8% in controls, P=0.295). Conclusions. This is the first study to evaluate the association of −174G/C and −572G/C polymorphisms of the IL-6 gene with RA in Mexican mestizo patients. These two polymorphisms were not associated with RA in the studied sample. Additional studies are required to evaluate if these IL-6 polymorphisms have relevance to the development of more severe disease. |
| format | Article |
| id | doaj-art-d17e95b20bbe4d9d81169f641be258f9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d17e95b20bbe4d9d81169f641be258f92025-02-03T01:24:13ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/959084959084The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control StudyS. A. Zavaleta-Muñiz0B. T. Martín-Márquez1L. Gonzalez-Lopez2N. G. Gonzalez-Montoya3M. L. Díaz-Toscano4J. M. Ponce-Guarneros5A. J. Ruiz-Padilla6M. Vázquez-Del Mercado7M. Maldonado-González8M. Fafutis-Morris9S. E. Flores-Martínez10E. A. Martínez-García11J. I. Gamez-Nava12Unidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, Guadalajara 44340, MexicoInstituto de Investigación en Reumatología y del Sistema Músculo Esquelético, CUCS, Universidad de Guadalajara, 44340 Guadalajara, MexicoDepartamento de Medicina Interna/Reumatología, Hospital General Regional 110 del Instituto Mexicano del Seguro Social (IMSS), 44710 Guadalajara, MexicoUnidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, Guadalajara 44340, MexicoDepartamento de Medicina Interna/Reumatología, Hospital General Regional 110 del Instituto Mexicano del Seguro Social (IMSS), 44710 Guadalajara, MexicoDepartamento de Medicina Interna/Reumatología, Hospital General Regional 110 del Instituto Mexicano del Seguro Social (IMSS), 44710 Guadalajara, MexicoDoctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, 44340 Guadalajara, MexicoInstituto de Investigación en Reumatología y del Sistema Músculo Esquelético, CUCS, Universidad de Guadalajara, 44340 Guadalajara, MexicoInstituto de Investigación en Reumatología y del Sistema Músculo Esquelético, CUCS, Universidad de Guadalajara, 44340 Guadalajara, MexicoDepartamento de Fisiología, CUCS, Universidad de Guadalajara, 44340 Guadalajara, MexicoDivisión de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), IMSS, 44340 Guadalajara, MexicoEscuela de Ciencias de la Salud, Universidad del Valle de México, Campus Zapopan, 45010 Zapopan, MexicoUnidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, Guadalajara 44340, MexicoObjective. There is a lack of information about the genotype frequencies of IL-6 −174G/C and −572G/C polymorphisms in Mexicans with rheumatoid arthritis (RA). Therefore, the aim of this study was to evaluate the association of the IL-6 −174G/C and −572G/C polymorphisms in Mexican mestizo with RA. Methods. We included 137 patients with RA and 102 healthy controls. Patients were assessed for clinical characteristics. IL-6 −174G/C and −572G/C polymorphisms were genotyped using PCR-RFLP analysis. Allele and genotype frequencies and the Hardy-Weinberg equilibrium were computed. Odds ratios (ORs) were computed to identify the risk for RA associated with the presence of GG genotype in comparison with the GC or CC genotypes. Results. The genotype −174GG occurred at a higher frequency in cases and controls (77.4% versus 78.4%, P=0.845). We found similar results for the genotype −572GG (54% in patients versus 60.8% in controls, P=0.295). Conclusions. This is the first study to evaluate the association of −174G/C and −572G/C polymorphisms of the IL-6 gene with RA in Mexican mestizo patients. These two polymorphisms were not associated with RA in the studied sample. Additional studies are required to evaluate if these IL-6 polymorphisms have relevance to the development of more severe disease.http://dx.doi.org/10.1155/2013/959084 |
| spellingShingle | S. A. Zavaleta-Muñiz B. T. Martín-Márquez L. Gonzalez-Lopez N. G. Gonzalez-Montoya M. L. Díaz-Toscano J. M. Ponce-Guarneros A. J. Ruiz-Padilla M. Vázquez-Del Mercado M. Maldonado-González M. Fafutis-Morris S. E. Flores-Martínez E. A. Martínez-García J. I. Gamez-Nava The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study Clinical and Developmental Immunology |
| title | The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study |
| title_full | The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study |
| title_fullStr | The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study |
| title_full_unstemmed | The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study |
| title_short | The −174G/C and −572G/C Interleukin 6 Promoter Gene Polymorphisms in Mexican Patients with Rheumatoid Arthritis: A Case-Control Study |
| title_sort | 174g c and 572g c interleukin 6 promoter gene polymorphisms in mexican patients with rheumatoid arthritis a case control study |
| url | http://dx.doi.org/10.1155/2013/959084 |
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