Inhibition of Selenoprotein I promotes ferroptosis and reverses resistance to platinum chemotherapy by impairing Akt phosphorylation in ovarian cancer

Inhibition of Selenoprotein I promotes ferroptosis and reverses resistance to platinum chemotherapy by impairing Akt phosphorylation in ovarian cancer

Abstract Ovarian cancer (OV) ranks among the deadliest gynecological cancer, known for its high risk of relapse and metastasis, and a general resistance to conventional platinum‐based chemotherapy. Selenoprotein I (SELENOI) is a crucial mediator implicated in human hereditary spastic paraplegia. How...

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Bibliographic Details
Main Authors: Jing Li, Mimi Chen, Dingwen Huang, Ziyin Li, Yu Chen, Jinhua Huang, Yuanqun Chen, Zhili Zhou, Zhiying Yu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:MedComm
Subjects:
Akt phosphorylation
chemoresistance
ferroptosis
ovarian cancer
SELENOI
Online Access:https://doi.org/10.1002/mco2.70033
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https://doi.org/10.1002/mco2.70033

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