Optimized in-solution enrichment of over a million ancient human SNPs

Optimized in-solution enrichment of over a million ancient human SNPs

Abstract Background In-solution hybridization enrichment of genetic markers is a method of choice in paleogenomic studies, where the DNA of interest is generally heavily fragmented and contaminated with environmental DNA, and where the retrieval of genetic data comparable between individuals is chal...

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Main Authors: Roberta Davidson, Xavier Roca-Rada, Shyamsundar Ravishankar, Leonard Taufik, Christian Haarkötter, Evelyn Collen, Matthew P. Williams, Peter Webb, M. Irfan Mahmud, Erlin Novita Idje Djami, Gludhug A. Purnomo, Cristina Santos, Assumpció Malgosa, Linda R. Manzanilla, Ana Maria Silva, Sofia Tereso, Vítor Matos, Pedro C. Carvalho, Teresa Fernandes, Anne-France Maurer, João C. Teixeira, Raymond Tobler, Lars Fehren-Schmitz, Bastien Llamas
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
Subjects:
Ancient DNA
Enrichment
Population genetics
Human paleogenomics
Online Access:https://doi.org/10.1186/s13059-025-03622-6
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