Differential susceptibility and role for senescence in CART cells based on costimulatory domains

Differential susceptibility and role for senescence in CART cells based on costimulatory domains

Abstract Despite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy. To mimic cancer relapse, we utilized an in vitro m...

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Main Authors: Ismail Can, Elizabeth L. Siegler, Olivia L. Sirpilla, Claudia Manriquez-Roman, Kun Yun, Carli M. Stewart, Jennifer M. Feigin, Makena L. Rodriguez, Omar L. Gutierrez-Ruiz, Ekene J. Ogbodo, Truc N. Huynh, Brooke L. Kimball, Long K. Mai, Mehrdad Hefazi, Lionel Kankeu Fonkoua, Hong Xia, Imene Hamaidi, Berke Alkan, Fatih Sezer, H. Atakan Ekiz, R. Leo Sakemura, Saad S. Kenderian
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Cancer
Subjects:
Chimeric antigen receptor T cell therapy
Senescence
Exhaustion
MYC
Immunotherapy
Online Access:https://doi.org/10.1186/s12943-025-02371-1
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https://doi.org/10.1186/s12943-025-02371-1

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