In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China

In vivo RNA-seq and infection model reveal the different infection and immune characteristics of B. pertussis strains in China

IntroductionVarious strains emerged in B. pertussis re-emergence, the pathogenic characteristics and mechanisms remain elusive. We aimed to explore the relationship between the in vivo transcriptome and colonization advantage of various pertussis clinical strains during the B. pertussis re-emergence...

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Main Authors: Weilun Zuo, Chen Wei, Meiyan He, Mengyao Zhang, Jiangli Liang, Xiao Ma, Na Gao, Qin Gu, Yan Ma, Jingyan Li, Shuyuan Liu, Yan Huang, Mingbo Sun, Li Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Bordetella pertussis
in vivo RNA
clinical strains
tracheal colonization
pertactin deficiency
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1547751/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1547751/full

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