Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2
Abstracts: The Chinese medicine Astragalus mongholicus Bunge has the effect of benefiting vital energy and activating blood circulation, and is commonly used clinically in the treatment of various cardiovascular diseases. Astragalus is not only a kind of traditional Chinese medicine, but is now also...
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Elsevier
2025-03-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000374 |
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| author | Dandan Liu Hewei Qin Guanghua Liu Yang Gao Yu Guo |
| author_facet | Dandan Liu Hewei Qin Guanghua Liu Yang Gao Yu Guo |
| author_sort | Dandan Liu |
| collection | DOAJ |
| description | Abstracts: The Chinese medicine Astragalus mongholicus Bunge has the effect of benefiting vital energy and activating blood circulation, and is commonly used clinically in the treatment of various cardiovascular diseases. Astragalus is not only a kind of traditional Chinese medicine, but is now also widely used in various kinds of health food. Astragaloside IV is the most abundant active ingredient in this herb. In addition, astragaloside IV has lipid-modulating and antioxidant pharmacological potential. The vasoprotective and anti-ferroptosis effects of astragaloside IV were determined by establishing a high-fat-fed ApoE−/− mouse model of AS and an ox-LDL-induced model of lipid damage in VECs. Lipid profile (TC, TG, LDL-C, HDLC), HE and local oil red O showed a reduction in atherosclerotic pathological damage and lipid deposition after astragaloside IV treatment. Astragaloside IV was then able to increase FTH1 and p62 expression, decrease NCOA4 and Beclin1 expression, and inhibit ferritin autophagy by activating Nrf2. Meanwhile, when ML385 inhibits Nrf2, astragaloside IV can diminish the expression of divalent iron, suppress iron death-related factors (FTH1, FTL, FPN, ACSL4), and alleviate disorders in iron metabolism and the overproduction of ROS. Collectively, these findings suggest that astragaloside IV can regulate autophagy-dependent NCOA4 and FTH1 expression through activation of Nrf2, thereby inhibiting autophagy. |
| format | Article |
| id | doaj-art-d0e0a19e279445898aa725109fb63811 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-d0e0a19e279445898aa725109fb638112025-02-06T05:11:27ZengElsevierJournal of Functional Foods1756-46462025-03-01126106695Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2Dandan Liu0Hewei Qin1Guanghua Liu2Yang Gao3Yu Guo4School of Rehabilitation Medicine, Henan University of Traditional Chinese Medicine, 450046 Zhengzhou, ChinaSchool of Rehabilitation Medicine, Henan University of Traditional Chinese Medicine, 450046 Zhengzhou, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, 450002 Zhengzhou, China; Corresponding author at: Department of Rehabilitation, the Second Affiliated Hospital of Henan University of Chinese Medicine, No.6 Dongfeng Road, Jinshui District, Zhengzhou 450002, China.College of Bone Injury, Henan University of Traditional Chinese Medicine, 450046 Zhengzhou, ChinaSchool of Rehabilitation Medicine, Henan University of Traditional Chinese Medicine, 450046 Zhengzhou, ChinaSchool of Rehabilitation Medicine, Henan University of Traditional Chinese Medicine, 450046 Zhengzhou, ChinaAbstracts: The Chinese medicine Astragalus mongholicus Bunge has the effect of benefiting vital energy and activating blood circulation, and is commonly used clinically in the treatment of various cardiovascular diseases. Astragalus is not only a kind of traditional Chinese medicine, but is now also widely used in various kinds of health food. Astragaloside IV is the most abundant active ingredient in this herb. In addition, astragaloside IV has lipid-modulating and antioxidant pharmacological potential. The vasoprotective and anti-ferroptosis effects of astragaloside IV were determined by establishing a high-fat-fed ApoE−/− mouse model of AS and an ox-LDL-induced model of lipid damage in VECs. Lipid profile (TC, TG, LDL-C, HDLC), HE and local oil red O showed a reduction in atherosclerotic pathological damage and lipid deposition after astragaloside IV treatment. Astragaloside IV was then able to increase FTH1 and p62 expression, decrease NCOA4 and Beclin1 expression, and inhibit ferritin autophagy by activating Nrf2. Meanwhile, when ML385 inhibits Nrf2, astragaloside IV can diminish the expression of divalent iron, suppress iron death-related factors (FTH1, FTL, FPN, ACSL4), and alleviate disorders in iron metabolism and the overproduction of ROS. Collectively, these findings suggest that astragaloside IV can regulate autophagy-dependent NCOA4 and FTH1 expression through activation of Nrf2, thereby inhibiting autophagy.http://www.sciencedirect.com/science/article/pii/S1756464625000374Astragaloside IVAtherosclerosisFerritin autophagyFerroptosisNrf2 pathway |
| spellingShingle | Dandan Liu Hewei Qin Guanghua Liu Yang Gao Yu Guo Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 Journal of Functional Foods Astragaloside IV Atherosclerosis Ferritin autophagy Ferroptosis Nrf2 pathway |
| title | Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 |
| title_full | Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 |
| title_fullStr | Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 |
| title_full_unstemmed | Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 |
| title_short | Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 |
| title_sort | astragaloside iv inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating nrf2 |
| topic | Astragaloside IV Atherosclerosis Ferritin autophagy Ferroptosis Nrf2 pathway |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000374 |
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