Reverse swing‐M, phase 1 study of repurposing mebendazole in recurrent high‐grade glioma

Reverse swing‐M, phase 1 study of repurposing mebendazole in recurrent high‐grade glioma

Abstract Background Relapsed high‐grade glioma has dismal outcomes. Mebendazole has shown promising activity against glioma in in‐vitro and in‐vivo studies. Hence, we undertook a phase 1 study to repurpose mebendazole in the treatment of glioblastoma. Methods We conducted a phase 1 study (accelerate...

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Main Authors: Vijay M. Patil, Arti Bhelekar, Nandini Menon, Atanu Bhattacharjee, Vijai Simha, Ram Abhinav, Anuja Abhyankar, Epari Sridhar, Abhishek Mahajan, Ameya D. Puranik, Nilendu Purandare, Amit Janu, Ankita Ahuja, Rahul Krishnatry, Tejpal Gupta, Rakesh Jalali
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Cancer Medicine
Subjects:
Checkpoint
Glioblastoma
High‐grade Glioma
Mebendazole
Recurrence
Repurposing
Online Access:https://doi.org/10.1002/cam4.3094
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https://doi.org/10.1002/cam4.3094

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