Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea
Multicentric Castleman’s disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its prognosis i...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2015/689206 |
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| author | Sarra Benmiloud Sana Chaouki Samir Atmani Moustapha Hida |
| author_facet | Sarra Benmiloud Sana Chaouki Samir Atmani Moustapha Hida |
| author_sort | Sarra Benmiloud |
| collection | DOAJ |
| description | Multicentric Castleman’s disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its prognosis is poor. We report a novel case of multicentric Castleman’s disease in a 13-year-old girl who had presented with chronic diarrhea as the only initial presenting symptom. The diagnosis of celiac or inflammatory bowel diseases was suspected, but two and a half years later, the diagnosis of multicentric Castleman’s disease was brought following the appearance of abdominal mass whose biopsy revealed Castleman’s disease in the plasma cell form. The outcome was favorable after treatment by corticosteroid, chemotherapy, and surgery. The occurrence of diarrhea as the initial symptom of multicentric Castleman’s disease without lymph node involvement is very rare. This case report underlines the diagnostic difficulties and the long interval between onset and diagnosis when diarrhea occurs first. |
| format | Article |
| id | doaj-art-d0d4830799e54825ab971c0261b3d25d |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-d0d4830799e54825ab971c0261b3d25d2025-02-03T01:01:56ZengWileyCase Reports in Pediatrics2090-68032090-68112015-01-01201510.1155/2015/689206689206Multicentric Castleman’s Disease in a Child Revealed by Chronic DiarrheaSarra Benmiloud0Sana Chaouki1Samir Atmani2Moustapha Hida3Unit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University Sidi Mohamed Ben Abdellah of Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University Sidi Mohamed Ben Abdellah of Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University Sidi Mohamed Ben Abdellah of Fez, MoroccoUnit of Pediatric Hematology-Oncology, Department of Pediatrics, University Hospital Hassan II, Faculty of Medicine and Pharmacy, University Sidi Mohamed Ben Abdellah of Fez, MoroccoMulticentric Castleman’s disease is a rare benign and unexplained lymphoproliferative disorder that is extremely uncommon in children. It presents with fever, systemic symptoms, generalized lymphadenopathy, and laboratory markers of inflammation. Its treatment is not standardized and its prognosis is poor. We report a novel case of multicentric Castleman’s disease in a 13-year-old girl who had presented with chronic diarrhea as the only initial presenting symptom. The diagnosis of celiac or inflammatory bowel diseases was suspected, but two and a half years later, the diagnosis of multicentric Castleman’s disease was brought following the appearance of abdominal mass whose biopsy revealed Castleman’s disease in the plasma cell form. The outcome was favorable after treatment by corticosteroid, chemotherapy, and surgery. The occurrence of diarrhea as the initial symptom of multicentric Castleman’s disease without lymph node involvement is very rare. This case report underlines the diagnostic difficulties and the long interval between onset and diagnosis when diarrhea occurs first.http://dx.doi.org/10.1155/2015/689206 |
| spellingShingle | Sarra Benmiloud Sana Chaouki Samir Atmani Moustapha Hida Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea Case Reports in Pediatrics |
| title | Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea |
| title_full | Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea |
| title_fullStr | Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea |
| title_full_unstemmed | Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea |
| title_short | Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea |
| title_sort | multicentric castleman s disease in a child revealed by chronic diarrhea |
| url | http://dx.doi.org/10.1155/2015/689206 |
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