Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device

Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device

IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease caused by the loss of upper and lower motor neurons. Mutations in the FUS/TLS gene have been reported as the second most common mutation in Japanese patients with familial ALS. In recent years, lower motor neu...

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Main Authors: Asako Otomo, Keiko Nishijima, Yuta Murakami, Mitsuru Ishikawa, Haruka Yudahira, Kento Shimakura, Hideyuki Okano, Masashi Aoki, Hiroshi Kimura, Shinji Hadano
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
iPSCs
microfluidic device
FUS/TLS
lower motor neurons
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1590732/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1590732/full

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