Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population
Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CA...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/2067632 |
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| author | Oksana S. Pogorielova Viktoriia V. Korniienko Yaroslav D. Chumachenko Olha A. Obukhova Igor Martsovenko Viktoriia Yu. Harbuzova |
| author_facet | Oksana S. Pogorielova Viktoriia V. Korniienko Yaroslav D. Chumachenko Olha A. Obukhova Igor Martsovenko Viktoriia Yu. Harbuzova |
| author_sort | Oksana S. Pogorielova |
| collection | DOAJ |
| description | Coronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (Pa=0.023; ORa = 0.299, 95% CI = 0.106–0.848) in Ukrainian population. |
| format | Article |
| id | doaj-art-d0c6c83ebe8c463284d630df77d936b3 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-d0c6c83ebe8c463284d630df77d936b32025-02-03T06:07:32ZengWileyCardiology Research and Practice2090-05972022-01-01202210.1155/2022/2067632Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian PopulationOksana S. Pogorielova0Viktoriia V. Korniienko1Yaroslav D. Chumachenko2Olha A. Obukhova3Igor Martsovenko4Viktoriia Yu. Harbuzova5Department of Internal Medicine with Center of Respiratory MedicineBiomedical Research CenterScientific Laboratory of Molecular Genetic StudiesDepartment of Physiology and Pathophysiology with Medical Biology CourseMunicipal Non-Profit Enterprise of Sumy Regional Council “Sumy Regional Cardiological Clinic”Scientific Laboratory of Molecular Genetic StudiesCoronary artery disease (CAD) is one of the leading causes of death in Europe. It is known that atherosclerosis is the primary risk factor of CAD development. MMP-9 is involved in all stages of atherosclerosis and thus may contribute to CAD emergence. To investigate the influence of MMP-9 on the (CAD) development 25 patients with intact coronary arteries (CA), 40 patients with acute coronary syndrome (ACS), and 63 patients with chronic coronary syndrome (CCS) were enrolled in the study. Real-time PCR was carried out for genotyping on the rs17567-polymorphic locus, and ELISA study was performed to measure the MMP-9 plasma concentration. It was found the lower risk of MI occurrence for AG-carriers (Pa=0.023; ORa = 0.299, 95% CI = 0.106–0.848) in Ukrainian population.http://dx.doi.org/10.1155/2022/2067632 |
| spellingShingle | Oksana S. Pogorielova Viktoriia V. Korniienko Yaroslav D. Chumachenko Olha A. Obukhova Igor Martsovenko Viktoriia Yu. Harbuzova Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population Cardiology Research and Practice |
| title | Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population |
| title_full | Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population |
| title_fullStr | Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population |
| title_full_unstemmed | Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population |
| title_short | Impact of MMP-9 Genetic Polymorphism and Concentration on the Development of Coronary Artery Disease in Ukrainian Population |
| title_sort | impact of mmp 9 genetic polymorphism and concentration on the development of coronary artery disease in ukrainian population |
| url | http://dx.doi.org/10.1155/2022/2067632 |
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