An Innovative Inhibitor with a New Chemical Moiety Aimed at Biliverdin IXβ Reductase for Thrombocytopenia and Resilient against Cellular Degradation

An Innovative Inhibitor with a New Chemical Moiety Aimed at Biliverdin IXβ Reductase for Thrombocytopenia and Resilient against Cellular Degradation

Biliverdin IXβ reductase (BLVRB) has emerged as a promising therapeutic target for thrombocytopenia due to its involvement in reactive oxygen species (ROS) mechanisms. During the pursuit of inhibitors targeting BLVRB, olsalazine (OSA) became apparent as one of the most potent candidates. However, th...

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Bibliographic Details
Main Authors: Hoe-Myung Jung, Jung-Hye Ha, Mark Vincent C. dela Cerna, Joseph A. Burlison, Joonhyeok Choi, Bo-Ram Kim, Jeong Kyu Bang, Kyoung-Seok Ryu, Donghan Lee
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Pharmaceutics
Subjects:
biliverdin IXβ reductase-inhibitor complex structure
azoreductase-resistant inhibitor
thrombocytopenia
NMR spectroscopy
X-ray crystallography
Online Access:https://www.mdpi.com/1999-4923/16/9/1148
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