Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells

Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells

Abstract Background Metabolism is error prone. For instance, the reduced forms of the central metabolic cofactors nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), can be converted into redox-inactive products, NADHX and NADPHX, through enzymatically c...

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Main Authors: Adhish S. Walvekar, Marc Warmoes, Dean Cheung, Tim Sikora, Najmesadat Seyedkatouli, Gemma Gomez-Giro, Sebastian Perrone, Lisa Dengler, François Unger, Bruno F. R. Santos, Floriane Gavotto, Xiangyi Dong, Julia Becker-Kettern, Yong-Jun Kwon, Christian Jäger, Jens C. Schwamborn, Nicole J. Van Bergen, John Christodoulou, Carole L. Linster
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Metabolite damage and repair
Inborn errors of metabolism
NAD(P)H hydration
NAXD
Serine biosynthesis
3-Phosphoglycerate dehydrogenase
Online Access:https://doi.org/10.1186/s11658-024-00681-8
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https://doi.org/10.1186/s11658-024-00681-8

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