Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features
Abstract Early detection of lung function impairment is crucial. However, the sensitivity of spirometry in detecting early lung function deterioration is limited. In this study, lungs of 3180 healthy participants scheduled for annual health check were screened. Electrical impedance tomography measur...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55505-2 |
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| author | Shuoyao Qu Enzhi Feng Daihan Dong Lin Yang Meng Dai Inéz Frerichs Shaojie Liu Yi Gao Jinping Zheng Liqiang Song Zhanqi Zhao |
| author_facet | Shuoyao Qu Enzhi Feng Daihan Dong Lin Yang Meng Dai Inéz Frerichs Shaojie Liu Yi Gao Jinping Zheng Liqiang Song Zhanqi Zhao |
| author_sort | Shuoyao Qu |
| collection | DOAJ |
| description | Abstract Early detection of lung function impairment is crucial. However, the sensitivity of spirometry in detecting early lung function deterioration is limited. In this study, lungs of 3180 healthy participants scheduled for annual health check were screened. Electrical impedance tomography measurements were conducted in 130 participants with normal spirometry for concept establishment phase and 105 for validation phase. A follow-up CT examination was suggested for participants with abnormal regional time constant or tobacco consumption ≥10 pack-years. Using CT as reference, the sensitivity and specificity of electrical impedance tomography-based screening were 81.3% and 50.0%, respectively in the concept establishment phase. In the validation phase, the sensitivity and specificity were 77.9% and 50.0%. In this study we show that conventional spirometry may not capture early changes that occur at a regional level. The regional time constant based on electrical impedance tomography can be a promising tool for early screening of lung function impairment. Clinical trial registration: ChiCTR2300076673, www.chictr.org.cn . |
| format | Article |
| id | doaj-art-d0adbe39a80441bcaa1a7217e4692a4b |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-d0adbe39a80441bcaa1a7217e4692a4b2025-01-19T12:29:42ZengNature PortfolioNature Communications2041-17232025-01-011611910.1038/s41467-024-55505-2Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological featuresShuoyao Qu0Enzhi Feng1Daihan Dong2Lin Yang3Meng Dai4Inéz Frerichs5Shaojie Liu6Yi Gao7Jinping Zheng8Liqiang Song9Zhanqi Zhao10Department of Pulmonary and Critical Care Medicine, Xijing Hospital, Air Force Medical UniversityNo. 941 Hospital of the Joint Support Force of People’s Liberation Army (PLA)Department of Pulmonary and Critical Care Medicine, Xijing Hospital, Air Force Medical UniversityDepartment of Aerospace Medicine, Air Force Medical UniversityDepartment of Biomedical Engineering, Air Force Medical UniversityDepartment of Anesthesiology and Intensive Care Medicine, University Medical Center of Schleswig-Holstein Campus KielNo. 941 Hospital of the Joint Support Force of People’s Liberation Army (PLA)Department of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Xijing Hospital, Air Force Medical UniversityDepartment of Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityAbstract Early detection of lung function impairment is crucial. However, the sensitivity of spirometry in detecting early lung function deterioration is limited. In this study, lungs of 3180 healthy participants scheduled for annual health check were screened. Electrical impedance tomography measurements were conducted in 130 participants with normal spirometry for concept establishment phase and 105 for validation phase. A follow-up CT examination was suggested for participants with abnormal regional time constant or tobacco consumption ≥10 pack-years. Using CT as reference, the sensitivity and specificity of electrical impedance tomography-based screening were 81.3% and 50.0%, respectively in the concept establishment phase. In the validation phase, the sensitivity and specificity were 77.9% and 50.0%. In this study we show that conventional spirometry may not capture early changes that occur at a regional level. The regional time constant based on electrical impedance tomography can be a promising tool for early screening of lung function impairment. Clinical trial registration: ChiCTR2300076673, www.chictr.org.cn .https://doi.org/10.1038/s41467-024-55505-2 |
| spellingShingle | Shuoyao Qu Enzhi Feng Daihan Dong Lin Yang Meng Dai Inéz Frerichs Shaojie Liu Yi Gao Jinping Zheng Liqiang Song Zhanqi Zhao Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features Nature Communications |
| title | Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features |
| title_full | Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features |
| title_fullStr | Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features |
| title_full_unstemmed | Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features |
| title_short | Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features |
| title_sort | early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features |
| url | https://doi.org/10.1038/s41467-024-55505-2 |
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