Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial
Background: Air pollution may impair child growth and cognitive development, with potential markers including birth length and head circumference. Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open label multi-country-randomized controlled trial, with 3200 pregnant w...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024007980 |
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| author | Hina Raheel Sheela Sinharoy Anaité Diaz-Artiga Sarada S. Garg Ajay Pillarisetti Kalpana Balakrishnan Marilu Chiang Amy Lovvorn Miles Kirby Usha Ramakrishnan Shirin Jabbarzadeh Alexie Mukeshimana Michael Johnson John P. McCracken Luke P. Naeher Ghislaine Rosa Jiantong Wang Joshua Rosenthal William Checkley Thomas F. Clasen Jennifer L. Peel Lisa M. Thompson |
| author_facet | Hina Raheel Sheela Sinharoy Anaité Diaz-Artiga Sarada S. Garg Ajay Pillarisetti Kalpana Balakrishnan Marilu Chiang Amy Lovvorn Miles Kirby Usha Ramakrishnan Shirin Jabbarzadeh Alexie Mukeshimana Michael Johnson John P. McCracken Luke P. Naeher Ghislaine Rosa Jiantong Wang Joshua Rosenthal William Checkley Thomas F. Clasen Jennifer L. Peel Lisa M. Thompson |
| author_sort | Hina Raheel |
| collection | DOAJ |
| description | Background: Air pollution may impair child growth and cognitive development, with potential markers including birth length and head circumference. Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open label multi-country-randomized controlled trial, with 3200 pregnant women aged 18–34 years (9–19 weeks of gestation) randomly assigned in a 1:1 ratio to receive liquefied petroleum gas (LPG) stove intervention compared to women continuing to cook with solid fuels for 18 months. Particulate matter ≤ 2.5 μm (PM2.5), black carbon (BC) and carbon monoxide (CO) 24-hour personal exposures were measured three times during pregnancy. Head circumference and length were measured < 24 h of birth. We conducted intention-to-treat and exposure–response analyses to determine the intervention effects and associations between household air pollution (HAP) exposure during pregnancy and head circumference, head circumference-for-gestational age Z-score, length, and length-for-gestational age Z-scores at birth. ClinicalTrials.gov. Results: Between May 2018, and Feb 2020, 3200 pregnant women were randomly assigned to intervention (n = 1593) and control groups (n = 1607) with 3060 births included in the analysis. There was a 71.9 % reduction in PM2.5 in the intervention group with similar reductions for BC and CO. Intention-to-treat analysis showed that the intervention did not affect head circumference (β = -0.01 cm, 95 %CI −0.11, 0.09), head circumference-for-gestational age Z-score (β = -0.01, 95 %CI −0.08, 0.07), or birth length (β = 0.14 cm, 95 %CI −0.01, 0.29) but did increase birth length-for-gestational age Z-score (β = 0.09, 95 %CI 0.01, 0.16). After covariate adjustment, exposure–response analysis revealed that each log-unit increase in BC was associated with a decrease in birth length-for-gestational age Z-score (β = -0.07, 95 %CI −0.13, −0.005). There was no evidence of hypothesized associations with PM2.5 or CO. Conclusion: An LPG intervention reduced HAP exposure during pregnancy but had minor effects on birth length-for-gestational age Z-score. Birth length-for-gestational age was only associated with BC.Clinical Trial Registration: The study has been registered with ClinicalTrials.gov (Identifier NCT02944682). |
| format | Article |
| id | doaj-art-d0a56c85c7094cada92085a62e2739e0 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj-art-d0a56c85c7094cada92085a62e2739e02025-01-24T04:44:04ZengElsevierEnvironment International0160-41202025-01-01195109211Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trialHina Raheel0Sheela Sinharoy1Anaité Diaz-Artiga2Sarada S. Garg3Ajay Pillarisetti4Kalpana Balakrishnan5Marilu Chiang6Amy Lovvorn7Miles Kirby8Usha Ramakrishnan9Shirin Jabbarzadeh10Alexie Mukeshimana11Michael Johnson12John P. McCracken13Luke P. Naeher14Ghislaine Rosa15Jiantong Wang16Joshua Rosenthal17William Checkley18Thomas F. Clasen19Jennifer L. Peel20Lisa M. Thompson21Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA; Corresponding author at: 1520 Clifton Road, NE Atlanta, GA, USA.Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, USACenter for Health Studies, Universidad del Valle de Guatemala, Guatemala City, GuatemalaICMR Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, IndiaDivision of Environmental Health Sciences, University of California at Berkeley, Berkeley, CA, USAICMR Center for Advanced Research on Air Quality, Climate and Health, Department of Environmental Health Engineering, Sri Ramachandra Institute for Higher Education and Research, Chennai, IndiaBiomedical Research Unit, Asociación Benéfica PRISMA, Lima, PeruGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, CA, USADepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USAHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, USADepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USAEagle Research Centre, Kigali, RwandaBerkeley Air Monitoring Group, Berkeley, CA, USADepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA, USADepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA, USAFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UKDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USADivision of Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, MD, USADivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USAGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, CA, USADepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USANell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, CA, USABackground: Air pollution may impair child growth and cognitive development, with potential markers including birth length and head circumference. Methods: The Household Air Pollution Intervention Network (HAPIN) trial was an open label multi-country-randomized controlled trial, with 3200 pregnant women aged 18–34 years (9–19 weeks of gestation) randomly assigned in a 1:1 ratio to receive liquefied petroleum gas (LPG) stove intervention compared to women continuing to cook with solid fuels for 18 months. Particulate matter ≤ 2.5 μm (PM2.5), black carbon (BC) and carbon monoxide (CO) 24-hour personal exposures were measured three times during pregnancy. Head circumference and length were measured < 24 h of birth. We conducted intention-to-treat and exposure–response analyses to determine the intervention effects and associations between household air pollution (HAP) exposure during pregnancy and head circumference, head circumference-for-gestational age Z-score, length, and length-for-gestational age Z-scores at birth. ClinicalTrials.gov. Results: Between May 2018, and Feb 2020, 3200 pregnant women were randomly assigned to intervention (n = 1593) and control groups (n = 1607) with 3060 births included in the analysis. There was a 71.9 % reduction in PM2.5 in the intervention group with similar reductions for BC and CO. Intention-to-treat analysis showed that the intervention did not affect head circumference (β = -0.01 cm, 95 %CI −0.11, 0.09), head circumference-for-gestational age Z-score (β = -0.01, 95 %CI −0.08, 0.07), or birth length (β = 0.14 cm, 95 %CI −0.01, 0.29) but did increase birth length-for-gestational age Z-score (β = 0.09, 95 %CI 0.01, 0.16). After covariate adjustment, exposure–response analysis revealed that each log-unit increase in BC was associated with a decrease in birth length-for-gestational age Z-score (β = -0.07, 95 %CI −0.13, −0.005). There was no evidence of hypothesized associations with PM2.5 or CO. Conclusion: An LPG intervention reduced HAP exposure during pregnancy but had minor effects on birth length-for-gestational age Z-score. Birth length-for-gestational age was only associated with BC.Clinical Trial Registration: The study has been registered with ClinicalTrials.gov (Identifier NCT02944682).http://www.sciencedirect.com/science/article/pii/S0160412024007980Birth lengthHead circumferenceHousehold air pollutionLPG stoveIntervention |
| spellingShingle | Hina Raheel Sheela Sinharoy Anaité Diaz-Artiga Sarada S. Garg Ajay Pillarisetti Kalpana Balakrishnan Marilu Chiang Amy Lovvorn Miles Kirby Usha Ramakrishnan Shirin Jabbarzadeh Alexie Mukeshimana Michael Johnson John P. McCracken Luke P. Naeher Ghislaine Rosa Jiantong Wang Joshua Rosenthal William Checkley Thomas F. Clasen Jennifer L. Peel Lisa M. Thompson Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial Environment International Birth length Head circumference Household air pollution LPG stove Intervention |
| title | Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial |
| title_full | Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial |
| title_fullStr | Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial |
| title_full_unstemmed | Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial |
| title_short | Effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth: A multi-country household air pollution intervention network (HAPIN) trial |
| title_sort | effects of a liquefied petroleum gas stove and fuel intervention on head circumference and length at birth a multi country household air pollution intervention network hapin trial |
| topic | Birth length Head circumference Household air pollution LPG stove Intervention |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024007980 |
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