Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome

Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome

Abstract Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS) is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase tafazzin. Altered cardiolipin remodeling affects mitochondrial inner membrane organization and function of mem...

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Main Authors: Arpita Chowdhury, Angela Boshnakovska, Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon, Ivan Silbern, Christian Lüchtenborg, Lukas Cyganek, Jan Prochazka, Radislav Sedlacek, Jiri Lindovsky, Dominic Wachs, Zuzana Nichtova, Dagmar Zudova, Gizela Koubkova, André Fischer, Henning Urlaub, Britta Brügger, Dörthe M Katschinski, Jan Dudek, Peter Rehling
Format: Article
Language:English
Published: Springer Nature 2023-08-01
Series:EMBO Molecular Medicine
Subjects:
Barth syndrome
cardiolipin
cardiomyopathy
mitochondria
tafazzin
Online Access:https://doi.org/10.15252/emmm.202317399
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