Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase
With the reaction between Cu(NO3)2·3H2O and 4-(2′,3′-dicarboxylphenoxy) benzoic acid (H3L), a semirigid trichromatic acid ligand, in the presence of N-donor co-ligand 1,2-bis(4-pyridyl) ethylene (bpe), two novel mixed-ligand coordination polymers (CPs), i.e., [Cu(H2L)2(bpe)(H2O)2]bpe·(H2O)4 (1) and...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/1621706 |
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| author | Wen-Ping Liu Tao Xue Yangchun Li Ruoyu Cui |
| author_facet | Wen-Ping Liu Tao Xue Yangchun Li Ruoyu Cui |
| author_sort | Wen-Ping Liu |
| collection | DOAJ |
| description | With the reaction between Cu(NO3)2·3H2O and 4-(2′,3′-dicarboxylphenoxy) benzoic acid (H3L), a semirigid trichromatic acid ligand, in the presence of N-donor co-ligand 1,2-bis(4-pyridyl) ethylene (bpe), two novel mixed-ligand coordination polymers (CPs), i.e., [Cu(H2L)2(bpe)(H2O)2]bpe·(H2O)4 (1) and [Cu3(L)2(bpe)3(H2O)4]·(H2O)6 (2), have been created under different solvent systems. Furthermore, the biological activity of compounds was evaluated, and the related mechanism was explored as well. Firstly, the enzyme-linked immunosorbent assay (ELISA) was conducted to measure the content of coagulation factors in the serum after compound treatment. In addition to this, the real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was conducted, and the inflammatory response in the brain was also determined. |
| format | Article |
| id | doaj-art-d064e74a7bb744bf999c5d6c9769eb97 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-d064e74a7bb744bf999c5d6c9769eb972025-02-03T05:58:21ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/1621706Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with AlteplaseWen-Ping Liu0Tao Xue1Yangchun Li2Ruoyu Cui3Department of NeurologyDepartment of NeurologyDepartment of MedicineDepartment of MedicineWith the reaction between Cu(NO3)2·3H2O and 4-(2′,3′-dicarboxylphenoxy) benzoic acid (H3L), a semirigid trichromatic acid ligand, in the presence of N-donor co-ligand 1,2-bis(4-pyridyl) ethylene (bpe), two novel mixed-ligand coordination polymers (CPs), i.e., [Cu(H2L)2(bpe)(H2O)2]bpe·(H2O)4 (1) and [Cu3(L)2(bpe)3(H2O)4]·(H2O)6 (2), have been created under different solvent systems. Furthermore, the biological activity of compounds was evaluated, and the related mechanism was explored as well. Firstly, the enzyme-linked immunosorbent assay (ELISA) was conducted to measure the content of coagulation factors in the serum after compound treatment. In addition to this, the real-time reverse transcription-polymerase chain reaction (RT-PCR) assay was conducted, and the inflammatory response in the brain was also determined.http://dx.doi.org/10.1155/2022/1621706 |
| spellingShingle | Wen-Ping Liu Tao Xue Yangchun Li Ruoyu Cui Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase Journal of Chemistry |
| title | Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase |
| title_full | Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase |
| title_fullStr | Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase |
| title_full_unstemmed | Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase |
| title_short | Two Mixed-Ligand Cu(II) Polymers: Treatment Activity on Acute Cerebral Infarction Combined with Alteplase |
| title_sort | two mixed ligand cu ii polymers treatment activity on acute cerebral infarction combined with alteplase |
| url | http://dx.doi.org/10.1155/2022/1621706 |
| work_keys_str_mv | AT wenpingliu twomixedligandcuiipolymerstreatmentactivityonacutecerebralinfarctioncombinedwithalteplase AT taoxue twomixedligandcuiipolymerstreatmentactivityonacutecerebralinfarctioncombinedwithalteplase AT yangchunli twomixedligandcuiipolymerstreatmentactivityonacutecerebralinfarctioncombinedwithalteplase AT ruoyucui twomixedligandcuiipolymerstreatmentactivityonacutecerebralinfarctioncombinedwithalteplase |