Structure of transmembrane AMPA receptor regulatory protein subunit γ2

Structure of transmembrane AMPA receptor regulatory protein subunit γ2

Abstract Transmembrane AMPA receptor regulatory proteins (TARPs) are claudin-like proteins that tightly regulate AMPA receptors (AMPARs) and are fundamental for excitatory neurotransmission. With cryo-electron microscopy (cryo-EM) we reconstruct the 36 kDa TARP subunit γ2 to 2.3 Å, which points to s...

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Main Authors: W. Dylan Hale, Alejandra Montaño Romero, Nicholas Koylass, Collin R. Warrick, Zhaozhu Qiu, Richard L. Huganir, Edward C. Twomey
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56027-1
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https://doi.org/10.1038/s41467-025-56027-1

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