Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study usi...

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Main Authors: Jye-Lin Hsu, Dick J H van den Boomen, Peter Tomasec, Michael P Weekes, Robin Antrobus, Richard J Stanton, Eva Ruckova, Daniel Sugrue, Gavin S Wilkie, Andrew J Davison, Gavin W G Wilkinson, Paul J Lehner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004811
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https://doi.org/10.1371/journal.ppat.1004811

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