The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks...

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Main Authors: Machteld M Tiemessen, Miranda R M Baert, Tom Schonewille, Martijn H Brugman, Farbod Famili, Daniela C F Salvatori, Jules P P Meijerink, Ugur Ozbek, Hans Clevers, Jacques J M van Dongen, Frank J T Staal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001430&type=printable
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