Effects of paclitaxel and methotrexate associated with cholesterol-rich nanoemulsions on ischemia-reperfusion injury after unilateral lung transplantation in rats

Abstract Currently, the barrier to successful lung transplantation is ischemia and reperfusion injury, which can lead to the development of bronchiolitis obliterans. Paclitaxel and methotrexate are drugs known to inhibit cell proliferation and have anti-inflammatory effects, and the association of t...

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Main Authors: Angela da Silva Battochio, Elaine Rufo Tavares, Aristides Tadeu Correia, Francine Maria de Almeida, Priscila Oliveira Carvalho, Maria Carolina Guido, Paulo Manuel Pêgo-Fernandes, Raul Cavalcante Maranhão, Rogerio Pazetti
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-81337-7
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