Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome
Persistent pulmonary hypertension is a very rare presentation of congenital virus infection. We discuss the case of complete congenital rubella syndrome presenting at echocardiography with pulmonary hypertension that worsened after ductus ligation. Cardiac catheterization showed a normal pulmonary...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2015/198570 |
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| author | Francesco Raimondi Fiorella Migliaro Elisa Di Pietro Francesco Borgia Antonio Rapacciuolo Letizia Capasso |
| author_facet | Francesco Raimondi Fiorella Migliaro Elisa Di Pietro Francesco Borgia Antonio Rapacciuolo Letizia Capasso |
| author_sort | Francesco Raimondi |
| collection | DOAJ |
| description | Persistent pulmonary hypertension is a very rare presentation of congenital virus infection. We discuss the case of complete congenital rubella syndrome presenting at echocardiography with pulmonary hypertension that worsened after ductus ligation. Cardiac catheterization showed a normal pulmonary valve and vascular tree but a PAP=40 mmHg. The infant promptly responded to inhaled nitric oxide while on mechanical ventilation and was later shifted to oral sildenafil. It is not clear whether our observation may be due to direct viral damage to the endothelium or to the rubella virus increasing the vascular tone via a metabolic derangement. |
| format | Article |
| id | doaj-art-d01c1720aa3b4a4d83452f1956df86a8 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-d01c1720aa3b4a4d83452f1956df86a82025-02-03T06:13:15ZengWileyCase Reports in Critical Care2090-64202090-64392015-01-01201510.1155/2015/198570198570Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella SyndromeFrancesco Raimondi0Fiorella Migliaro1Elisa Di Pietro2Francesco Borgia3Antonio Rapacciuolo4Letizia Capasso5Division of Neonatology, Section of Pediatrics, Department of Translational Medical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, ItalyDivision of Neonatology, Section of Pediatrics, Department of Translational Medical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, ItalyDivision of Cardiology, Department of Advanced Biomedical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, ItalyDivision of Cardiology, Department of Advanced Biomedical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, ItalyDivision of Cardiology, Department of Advanced Biomedical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, ItalyDivision of Neonatology, Section of Pediatrics, Department of Translational Medical Sciences, Università “Federico II”, Via Pansini 5, 80131 Naples, ItalyPersistent pulmonary hypertension is a very rare presentation of congenital virus infection. We discuss the case of complete congenital rubella syndrome presenting at echocardiography with pulmonary hypertension that worsened after ductus ligation. Cardiac catheterization showed a normal pulmonary valve and vascular tree but a PAP=40 mmHg. The infant promptly responded to inhaled nitric oxide while on mechanical ventilation and was later shifted to oral sildenafil. It is not clear whether our observation may be due to direct viral damage to the endothelium or to the rubella virus increasing the vascular tone via a metabolic derangement.http://dx.doi.org/10.1155/2015/198570 |
| spellingShingle | Francesco Raimondi Fiorella Migliaro Elisa Di Pietro Francesco Borgia Antonio Rapacciuolo Letizia Capasso Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome Case Reports in Critical Care |
| title | Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome |
| title_full | Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome |
| title_fullStr | Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome |
| title_full_unstemmed | Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome |
| title_short | Nitric Oxide-Sensitive Pulmonary Hypertension in Congenital Rubella Syndrome |
| title_sort | nitric oxide sensitive pulmonary hypertension in congenital rubella syndrome |
| url | http://dx.doi.org/10.1155/2015/198570 |
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