The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury

Perinatal brain injury frequently complicates preterm birth and leads to significant long-term morbidity. Cytokines and inflammatory cells are mediators in the common pathways associated with perinatal brain injury induced by a variety of insults, such as hypoxic-ischemic injury, reperfusion injury,...

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Main Authors: Ryan M. McAdams, Sandra E. Juul
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2012/561494
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author Ryan M. McAdams
Sandra E. Juul
author_facet Ryan M. McAdams
Sandra E. Juul
author_sort Ryan M. McAdams
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description Perinatal brain injury frequently complicates preterm birth and leads to significant long-term morbidity. Cytokines and inflammatory cells are mediators in the common pathways associated with perinatal brain injury induced by a variety of insults, such as hypoxic-ischemic injury, reperfusion injury, toxin-mediated injury, and infection. This paper examines our current knowledge regarding cytokine-related perinatal brain injury and specifically discusses strategies for attenuating cytokine-mediated brain damage.
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spelling doaj-art-d00fd008b4674b32bba7dcccc0a2b5032025-02-03T05:43:56ZengWileyNeurology Research International2090-18522090-18602012-01-01201210.1155/2012/561494561494The Role of Cytokines and Inflammatory Cells in Perinatal Brain InjuryRyan M. McAdams0Sandra E. Juul1Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195-6320, USADivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA 98195-6320, USAPerinatal brain injury frequently complicates preterm birth and leads to significant long-term morbidity. Cytokines and inflammatory cells are mediators in the common pathways associated with perinatal brain injury induced by a variety of insults, such as hypoxic-ischemic injury, reperfusion injury, toxin-mediated injury, and infection. This paper examines our current knowledge regarding cytokine-related perinatal brain injury and specifically discusses strategies for attenuating cytokine-mediated brain damage.http://dx.doi.org/10.1155/2012/561494
spellingShingle Ryan M. McAdams
Sandra E. Juul
The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
Neurology Research International
title The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
title_full The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
title_fullStr The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
title_full_unstemmed The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
title_short The Role of Cytokines and Inflammatory Cells in Perinatal Brain Injury
title_sort role of cytokines and inflammatory cells in perinatal brain injury
url http://dx.doi.org/10.1155/2012/561494
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