Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis
Several organic pollutants, including dioxins, furans, and coplanar polychlorinated biphenyls (PCBs), have become a growing concern due to their significant capacity for accumulation and migration across regions, as well as their extended half-lives and relatively high toxicity. Our study aimed to a...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015392 |
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| author | Jiaxing Tan Ying Gao Yuanlin Xia Peiyan Sun Wei Qin |
| author_facet | Jiaxing Tan Ying Gao Yuanlin Xia Peiyan Sun Wei Qin |
| author_sort | Jiaxing Tan |
| collection | DOAJ |
| description | Several organic pollutants, including dioxins, furans, and coplanar polychlorinated biphenyls (PCBs), have become a growing concern due to their significant capacity for accumulation and migration across regions, as well as their extended half-lives and relatively high toxicity. Our study aimed to assess the impact of these pollutants on mortality, inflammatory states, and chronic diseases. Exposure was quantified in serum through high-resolution gas chromatography and isotope-dilution high-resolution mass spectrometry. Statistical analyses employed multivariate Cox regression, multivariate logistic regression, restricted cubic splines and subgroup analysis. The results indicated a significant increase in mortality (p < 0.05) associated with the seven substances classified as dioxins, furans, and PCBs. Moreover, these pollutants were linked to a higher incidence of chronic diseases, including hematological disorders, chronic kidney disease, hypertension, and diabetes (p < 0.05). Additionally, a robust correlation was observed between serum C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) concentrations and these substances, revealing their proinflammatory effects at specific concentrations. Consequently, our research unmasked that exposure to dioxins, furans, and coplanar PCBs could be associated with an elevated mortality rate, increased inflammatory conditions, and a higher incidence of chronic diseases. We proposed that exposure to these pollutants may initiate various afflictions by activating the inflammatory system, ultimately resulting in increased mortality. However, this hypothesis requires further empirical investigation to validate its assertions. |
| format | Article |
| id | doaj-art-cffcf4961a7f4a9e9c29dee6012a9622 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-cffcf4961a7f4a9e9c29dee6012a96222025-01-23T05:25:39ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117463Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysisJiaxing Tan0Ying Gao1Yuanlin Xia2Peiyan Sun3Wei Qin4Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaSchool of Mechanical Engineering, Sichuan University, Chengdu, Sichuan, ChinaDivision of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDivision of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Corresponding author.Several organic pollutants, including dioxins, furans, and coplanar polychlorinated biphenyls (PCBs), have become a growing concern due to their significant capacity for accumulation and migration across regions, as well as their extended half-lives and relatively high toxicity. Our study aimed to assess the impact of these pollutants on mortality, inflammatory states, and chronic diseases. Exposure was quantified in serum through high-resolution gas chromatography and isotope-dilution high-resolution mass spectrometry. Statistical analyses employed multivariate Cox regression, multivariate logistic regression, restricted cubic splines and subgroup analysis. The results indicated a significant increase in mortality (p < 0.05) associated with the seven substances classified as dioxins, furans, and PCBs. Moreover, these pollutants were linked to a higher incidence of chronic diseases, including hematological disorders, chronic kidney disease, hypertension, and diabetes (p < 0.05). Additionally, a robust correlation was observed between serum C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) concentrations and these substances, revealing their proinflammatory effects at specific concentrations. Consequently, our research unmasked that exposure to dioxins, furans, and coplanar PCBs could be associated with an elevated mortality rate, increased inflammatory conditions, and a higher incidence of chronic diseases. We proposed that exposure to these pollutants may initiate various afflictions by activating the inflammatory system, ultimately resulting in increased mortality. However, this hypothesis requires further empirical investigation to validate its assertions.http://www.sciencedirect.com/science/article/pii/S0147651324015392DioxinsFuransCoplanar polychlorinated biphenylsMortalityInflammatory states |
| spellingShingle | Jiaxing Tan Ying Gao Yuanlin Xia Peiyan Sun Wei Qin Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis Ecotoxicology and Environmental Safety Dioxins Furans Coplanar polychlorinated biphenyls Mortality Inflammatory states |
| title | Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis |
| title_full | Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis |
| title_fullStr | Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis |
| title_full_unstemmed | Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis |
| title_short | Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis |
| title_sort | investigating the impact of dioxins furans and coplanar polychlorinated biphenyls on mortality inflammatory states and chronic diseases an integrative epidemiological analysis |
| topic | Dioxins Furans Coplanar polychlorinated biphenyls Mortality Inflammatory states |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015392 |
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