NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/β-catenin signaling pathway in colorectal cancer

NEK2 promotes cancer cell progression and 5-fluorouracil resistance via the Wnt/β-catenin signaling pathway in colorectal cancer

Abstract Background Never-in-mitosis gene A-related-kinase-2 (NEK2) plays a pivotal role in malignant progression and chemotherapy sensitivity. This study aimed to elucidate the role of NEK2 in colorectal cancer (CRC) and its potential contribution to 5-fluorouracil (5‑FU) resistance mechanisms. Met...

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Bibliographic Details
Main Authors: Facai Cui, Yu Chen, Xiaoyu Wu, Weifeng Zhao
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Colorectal cancer
NEK2
Proliferation
Migration
5-Fluorouracil resistance
Wnt/β-catenin signaling pathway
Online Access:https://doi.org/10.1007/s12672-025-02154-6
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https://doi.org/10.1007/s12672-025-02154-6

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