Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case–control study on Algerian population

Association of MTHFD1G1958A, MTHFD1T401C, and DHFR-19bp variants with sperm criteria and unexplained male infertility: a case–control study on Algerian population

Abstract Background Methylenetetrahydrofolate dehydrogenase (MTHFD1) and Dihydrofolate reductase (DHFR) are pivotal enzymes in the folate metabolic pathway, playing essential roles in DNA synthesis, repair, and methylation processes critical for spermatogenesis. Numerous studies have implicated gene...

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Bibliographic Details
Main Authors: Nour El Houda Bousnane, Abed Alkarem Abu Alhaija, Housna Labed, Anissa Fizazi, Chahinez Amira Dahmani, May Fouad Sadiq
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:Middle East Fertility Society Journal
Subjects:
Male infertility
MTHFD1C401T
MTHFD1G1958A
DHFR-19bp
Semen criteria
Folate metabolism
Online Access:https://doi.org/10.1186/s43043-025-00223-y
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https://doi.org/10.1186/s43043-025-00223-y

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