The Controversial Role of Microglia in Malignant Gliomas
Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs c...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/285246 |
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| _version_ | 1832554457341100032 |
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| author | Jun Wei Konrad Gabrusiewicz Amy Heimberger |
| author_facet | Jun Wei Konrad Gabrusiewicz Amy Heimberger |
| author_sort | Jun Wei |
| collection | DOAJ |
| description | Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions. |
| format | Article |
| id | doaj-art-cf5d74c638424e29ba21f9197b65742d |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-cf5d74c638424e29ba21f9197b65742d2025-02-03T05:51:29ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/285246285246The Controversial Role of Microglia in Malignant GliomasJun Wei0Konrad Gabrusiewicz1Amy Heimberger2Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-1402, USADepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-1402, USADepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-1402, USAMalignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.http://dx.doi.org/10.1155/2013/285246 |
| spellingShingle | Jun Wei Konrad Gabrusiewicz Amy Heimberger The Controversial Role of Microglia in Malignant Gliomas Clinical and Developmental Immunology |
| title | The Controversial Role of Microglia in Malignant Gliomas |
| title_full | The Controversial Role of Microglia in Malignant Gliomas |
| title_fullStr | The Controversial Role of Microglia in Malignant Gliomas |
| title_full_unstemmed | The Controversial Role of Microglia in Malignant Gliomas |
| title_short | The Controversial Role of Microglia in Malignant Gliomas |
| title_sort | controversial role of microglia in malignant gliomas |
| url | http://dx.doi.org/10.1155/2013/285246 |
| work_keys_str_mv | AT junwei thecontroversialroleofmicrogliainmalignantgliomas AT konradgabrusiewicz thecontroversialroleofmicrogliainmalignantgliomas AT amyheimberger thecontroversialroleofmicrogliainmalignantgliomas AT junwei controversialroleofmicrogliainmalignantgliomas AT konradgabrusiewicz controversialroleofmicrogliainmalignantgliomas AT amyheimberger controversialroleofmicrogliainmalignantgliomas |