A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey
Background. Pain is frequent in Parkinson’s disease (PD) and Parkinson-plus syndrome. This study aimed to assess the prevalence, characteristics, therapy (especially the effect of dopaminergic therapy), and associated symptoms of pain in Parkinson's disease and multiple system atrophy (MSA) pat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2019/3150306 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562639003189248 |
|---|---|
| author | He-Yang You Lei Wu Hai-Ting Yang Chen Yang Xiao-Ling Ding |
| author_facet | He-Yang You Lei Wu Hai-Ting Yang Chen Yang Xiao-Ling Ding |
| author_sort | He-Yang You |
| collection | DOAJ |
| description | Background. Pain is frequent in Parkinson’s disease (PD) and Parkinson-plus syndrome. This study aimed to assess the prevalence, characteristics, therapy (especially the effect of dopaminergic therapy), and associated symptoms of pain in Parkinson's disease and multiple system atrophy (MSA) patients. Methods. Seventy-one PD patients, sixty-five MSA patients, and forty age-matched healthy controls were enrolled and evaluated by using the German pain questionnaire and visual analogue scale (VAS). In addition, the influence of pain in PD patients on anxiety, depression, and the quality of life was assessed with the Hospital Anxiety and Depression Scale (HADS) and Parkinson’s Disease Questionnaire (PDQ-39). Results. Compared to that of the healthy controls, the PD and MSA patients had a significantly higher presence of pain (P<0.01, P<0.01). PD patients had a higher presence of pain than MSA patients (P=0.007). No difference in VAS scores was observed between the PD and MSA patients (P=0.148). A total of 21 PD patients (42.85%) with pain and 13 MSA patients (43.33%) with pain received treatment. A total of 13 PD patients with pain and 6 MSA patients with pain had an improved pain intensity after using dopaminergic medication. The differences in the disease duration, Hoehn and Yahr stages, and scores on the Unified Parkinson’s Disease Rating Scale motor score, HAD-D, HAD-A, and PDQ-39 were significant between the PD patients with and without pain. Conclusion. PD and MSA patients are prone to pain with insufficient treatment. Pain interventions should be provided as soon as possible to improve the patient’s life. |
| format | Article |
| id | doaj-art-cf504ae3bf4b43ed8e00b03f1082035a |
| institution | Kabale University |
| issn | 1203-6765 1918-1523 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-cf504ae3bf4b43ed8e00b03f1082035a2025-02-03T01:22:17ZengWileyPain Research and Management1203-67651918-15232019-01-01201910.1155/2019/31503063150306A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional SurveyHe-Yang You0Lei Wu1Hai-Ting Yang2Chen Yang3Xiao-Ling Ding4Department of Neurology, Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230000, ChinaDepartment of Neurology, Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230000, ChinaDepartment of Neurology, Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230000, ChinaDepartment of Neurology, Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230000, ChinaDepartment of Neurology, Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230000, ChinaBackground. Pain is frequent in Parkinson’s disease (PD) and Parkinson-plus syndrome. This study aimed to assess the prevalence, characteristics, therapy (especially the effect of dopaminergic therapy), and associated symptoms of pain in Parkinson's disease and multiple system atrophy (MSA) patients. Methods. Seventy-one PD patients, sixty-five MSA patients, and forty age-matched healthy controls were enrolled and evaluated by using the German pain questionnaire and visual analogue scale (VAS). In addition, the influence of pain in PD patients on anxiety, depression, and the quality of life was assessed with the Hospital Anxiety and Depression Scale (HADS) and Parkinson’s Disease Questionnaire (PDQ-39). Results. Compared to that of the healthy controls, the PD and MSA patients had a significantly higher presence of pain (P<0.01, P<0.01). PD patients had a higher presence of pain than MSA patients (P=0.007). No difference in VAS scores was observed between the PD and MSA patients (P=0.148). A total of 21 PD patients (42.85%) with pain and 13 MSA patients (43.33%) with pain received treatment. A total of 13 PD patients with pain and 6 MSA patients with pain had an improved pain intensity after using dopaminergic medication. The differences in the disease duration, Hoehn and Yahr stages, and scores on the Unified Parkinson’s Disease Rating Scale motor score, HAD-D, HAD-A, and PDQ-39 were significant between the PD patients with and without pain. Conclusion. PD and MSA patients are prone to pain with insufficient treatment. Pain interventions should be provided as soon as possible to improve the patient’s life.http://dx.doi.org/10.1155/2019/3150306 |
| spellingShingle | He-Yang You Lei Wu Hai-Ting Yang Chen Yang Xiao-Ling Ding A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey Pain Research and Management |
| title | A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey |
| title_full | A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey |
| title_fullStr | A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey |
| title_full_unstemmed | A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey |
| title_short | A Comparison of Pain between Parkinson’s Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey |
| title_sort | comparison of pain between parkinson s disease and multiple system atrophy a clinical cross sectional survey |
| url | http://dx.doi.org/10.1155/2019/3150306 |
| work_keys_str_mv | AT heyangyou acomparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT leiwu acomparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT haitingyang acomparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT chenyang acomparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT xiaolingding acomparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT heyangyou comparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT leiwu comparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT haitingyang comparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT chenyang comparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey AT xiaolingding comparisonofpainbetweenparkinsonsdiseaseandmultiplesystematrophyaclinicalcrosssectionalsurvey |