Significance and Correlation of Lupus Anticoagulant and Anticardiolipin Antibody Assay in High-risk Pregnancy
Background: Antiphospholipid antibodies (aPL), a heterogeneous group of circulating antibodies including lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), & anti-beta-2-glycoprotein 1 antibodies (aβ2GP1) that have been associated with increased risks for thrombosis and adverse obstetr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Marine Medical Society |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jmms.jmms_85_24 |
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| Summary: | Background:
Antiphospholipid antibodies (aPL), a heterogeneous group of circulating antibodies including lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), & anti-beta-2-glycoprotein 1 antibodies (aβ2GP1) that have been associated with increased risks for thrombosis and adverse obstetric outcomes.
Aims and Objectives:
The lupus anticoagulant tests have variable sensitivity of different clot-based assays i.e. aPTT-LA and dRVVT. The utility & comparison of each lupus anticoagulant assay will be analyzed in high-risk pregnancy clinics.
Materials and Methods:
This retrospective and prospective observational study was conducted over 200 high risk pregnancy cases from Nov 2017 to Jan 2018 at a tertiary care Armed Forces Institute. Equal number of high risk pregnancy cases as patients & normal antenatal patients matched for age as controls were included. 10 ml venous blood collected in tubes in a 9:1 ratio of blood to 3.2% trisodium citrate solution for lupus anticoagulant assay & 3 ml venous sample collected in serum vacutainer for anticardiolipin antibody assays. The STA-Staclot dRVV Screen and STA-Staclot dRVV Confirm kits were used for the detection of lupus anticoagulants in the plasma of patients. The Chi square test & results were analyzed using SPSS version 20.
Results:
A statistically significant positive association between history of IUGR with aCL IgG/IgM antibodies (p-value 0.008) and an insignificant association with the LAC assay was observed.
Conclusion:
Using both aPTT-LA & dRVVT tests as per ISTH recommendation resulted in more prevalence of LAC (24.6%). |
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| ISSN: | 0975-3605 2589-1235 |