Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020
Objectives To investigate the independent and collective impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB).Design This was a retrospective cohort study.Setting Shandong, China.Participants Patients with newly diagnosed TB from 1 January 2004 t...
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BMJ Publishing Group
2022-07-01
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| author | Yi-Fan Li Yao Liu Qi Fu Wan-mei Song Jin-yue Liu Qian-yun Zhang Ting-ting Xu Shi-jin Li Qi-qi An Si-qi Liu Huai-chen Li Ning Ning Tao Xue-han Zhu Chun-bao Yu Jihua Dong |
| author_facet | Yi-Fan Li Yao Liu Qi Fu Wan-mei Song Jin-yue Liu Qian-yun Zhang Ting-ting Xu Shi-jin Li Qi-qi An Si-qi Liu Huai-chen Li Ning Ning Tao Xue-han Zhu Chun-bao Yu Jihua Dong |
| author_sort | Yi-Fan Li |
| collection | DOAJ |
| description | Objectives To investigate the independent and collective impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB).Design This was a retrospective cohort study.Setting Shandong, China.Participants Patients with newly diagnosed TB from 1 January 2004 to 31 December 2020 were collected. Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information on drug susceptibility testing results, smoking or drinking habits; bacteriological identification as non-tuberculous mycobacteria.Primary and secondary outcome measures Patients were classified into four groups including smokers only (G1), drinker only (G2), smoker +drinker (G3), non-smoker +non-drinker group (G0). We described the drug-resistant profiles, clinical factors and calculated the ORs of different drug-resistance among G1, G2, G3, compared with G0 through univariate and multivariate logistics regression models.Results Of the 7996 TB cases enrolled, the proportions of G1, G2, G3 and G0 were 8.25%, 3.89%, 16.46% and 71.40%, respectively. The rates of drug-resistant (DR)-TB, mono-resistant TB, multidrug resistant (MDR)-TB, polydrug resistant TB in G1, G2, G3 and G0 were 19.24%/16.4%/17.33%/19.08%, 11.52%/8.68%/10.94%/11.63%, 3.03%/2.57%/2.96%/3.66% and 4.70%/4.82%/3.34%/ 4.08%, respectively. G3 had a higher risk of MDR1: isoniazid +rifampin (adjusted OR (aOR)=1.91, 95% CI: 1.036 to 3.532), but had a lower risk of DR-TB (aOR=0.84, 95% CI: 0.71 to 0.99), rifampin-related resistance (aOR=0.68, 95% CI: 0.49 to 0.93), streptomycin-related resistance (aOR=0.82, 95% CI: 0.68 to 0.99), ethambutol-related resistance (aOR=0.57, 95% CI: 0.34 to 0.95), MDR3: isoniazid +rifampin+streptomycin (aOR=0.41, 95% CI: 0.19 to 0.85), any isoniazid +streptomycin resistance (aOR=0.85, 95% CI: 0.71 to 1.00). However, there were no significant differences between G1 and G0, G2 and G0 in all drug-resistant subtypes. Those patients with cavity had a higher risk of DR-TB among G3 (OR=1.35, 95% CI: 1.01 to 1.81).Conclusion Although we did not found an independent impact of alcohol drinking or tobacco smoking on TB drug-resistance, respectively, these two habits had a combined effect on TB drug-resistance. |
| format | Article |
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| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-cf45fb55b113482daad93e5b10c16e282025-01-31T18:05:11ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2021-059149Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020Yi-Fan Li0Yao Liu1Qi Fu2Wan-mei Song3Jin-yue Liu4Qian-yun Zhang5Ting-ting Xu6Shi-jin Li7Qi-qi An8Si-qi Liu9Huai-chen Li10Ning Ning Tao11Xue-han Zhu12Chun-bao Yu13Jihua Dong141 Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, ChinaDepartment of Respiratory and Critical Care Medicine, Huazhong University of Science and Technology, Wuhan, China3 Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China4 Department of Medical Ultrasound, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging, Jinan, Shandong, China2 Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China3 Department of Respiratory Medicine, Chengwu People`s Hospital, Heze, Shandong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital, Jinan, Shandong, China6 Katharine Hsu International Research Center of Human Infectious Diseases, Shandong Provincial Chest Hospital, Jinan, Shandong, China8 Department of Respiratory Medicine, Heze Mudan People`s Hospital, Heze, Shandong, ChinaObjectives To investigate the independent and collective impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB).Design This was a retrospective cohort study.Setting Shandong, China.Participants Patients with newly diagnosed TB from 1 January 2004 to 31 December 2020 were collected. Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information on drug susceptibility testing results, smoking or drinking habits; bacteriological identification as non-tuberculous mycobacteria.Primary and secondary outcome measures Patients were classified into four groups including smokers only (G1), drinker only (G2), smoker +drinker (G3), non-smoker +non-drinker group (G0). We described the drug-resistant profiles, clinical factors and calculated the ORs of different drug-resistance among G1, G2, G3, compared with G0 through univariate and multivariate logistics regression models.Results Of the 7996 TB cases enrolled, the proportions of G1, G2, G3 and G0 were 8.25%, 3.89%, 16.46% and 71.40%, respectively. The rates of drug-resistant (DR)-TB, mono-resistant TB, multidrug resistant (MDR)-TB, polydrug resistant TB in G1, G2, G3 and G0 were 19.24%/16.4%/17.33%/19.08%, 11.52%/8.68%/10.94%/11.63%, 3.03%/2.57%/2.96%/3.66% and 4.70%/4.82%/3.34%/ 4.08%, respectively. G3 had a higher risk of MDR1: isoniazid +rifampin (adjusted OR (aOR)=1.91, 95% CI: 1.036 to 3.532), but had a lower risk of DR-TB (aOR=0.84, 95% CI: 0.71 to 0.99), rifampin-related resistance (aOR=0.68, 95% CI: 0.49 to 0.93), streptomycin-related resistance (aOR=0.82, 95% CI: 0.68 to 0.99), ethambutol-related resistance (aOR=0.57, 95% CI: 0.34 to 0.95), MDR3: isoniazid +rifampin+streptomycin (aOR=0.41, 95% CI: 0.19 to 0.85), any isoniazid +streptomycin resistance (aOR=0.85, 95% CI: 0.71 to 1.00). However, there were no significant differences between G1 and G0, G2 and G0 in all drug-resistant subtypes. Those patients with cavity had a higher risk of DR-TB among G3 (OR=1.35, 95% CI: 1.01 to 1.81).Conclusion Although we did not found an independent impact of alcohol drinking or tobacco smoking on TB drug-resistance, respectively, these two habits had a combined effect on TB drug-resistance.https://bmjopen.bmj.com/content/12/7/e059149.full |
| spellingShingle | Yi-Fan Li Yao Liu Qi Fu Wan-mei Song Jin-yue Liu Qian-yun Zhang Ting-ting Xu Shi-jin Li Qi-qi An Si-qi Liu Huai-chen Li Ning Ning Tao Xue-han Zhu Chun-bao Yu Jihua Dong Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 BMJ Open |
| title | Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 |
| title_full | Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 |
| title_fullStr | Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 |
| title_full_unstemmed | Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 |
| title_short | Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 |
| title_sort | impact of alcohol drinking and tobacco smoking on the drug resistance of newly diagnosed tuberculosis a retrospective cohort study in shandong china during 2004 2020 |
| url | https://bmjopen.bmj.com/content/12/7/e059149.full |
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