Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteraemia (SAFE trial): protocol for a randomised, controlled, open-label, non-inferiority trial comparing 4 and 6 weeks of antibiotic treatment

Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteraemia (SAFE trial): protocol for a randomised, controlled, open-label, non-inferiority trial comparing 4 and 6 weeks of antibiotic treatment

Introduction A major knowledge gap in the treatment of complicated Staphylococcus aureus bacteraemia (SAB) is the optimal duration of antibiotic therapy. Safe shortening of antibiotic therapy has the potential to reduce adverse drug events, length of hospital stay and costs. The objective of the SAF...

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Main Authors: N Roescher, JM Prins, JTM van der Meer, HI Bax, R Soetekouw, MGJ de Boer, LBS Gelinck, JJ Oosterheert, MA van Agtmael, M Berrevoets, DTP Buis, CH van Werkhoven, MJM Bonten, JE Bosmans, J Branger, S Douiyeb, E Jong, AJJ Lammers, E Sieswerda, JE Stalenhoef, TW Van der Vaart, EA Bij de Vaate, NJ Verkaik, MGA Van Vonderen, PJ De Vries, KCE Sigaloff, E Botman, A Van den Broek, L Buitenhuis, E Buitenwerf, A S Cents, N Engels, J L J Hanssen, A J Meinders, F P N Mollema, L Nagelmaker, M L M van Doorn-Schepens, P Thomopoulos, M Timmer, B van der Wiel
Format: Article
Language:English
Published: BMJ Publishing Group 2023-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/13/4/e068295.full
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