BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis

BRD4 acts as a transcriptional repressor of RhoB to inhibit terminal erythropoiesis

Abstract Background Terminal erythropoiesis is a complex multistep process involving coordination of gene transcription and dramatic nuclear condensation, which leads to the expulsion of nuclei to generate reticulocytes. However, we lack a comprehensive understanding of the key transcriptional and e...

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Main Authors: Yijin Chen, Dawei Huo, Ye Meng, Jie Zhang, Mengmeng Huang, Qian Luo, Yulin Xu, Haiqiong Zheng, Yingli Han, Xiangjun Zeng, Yanjuan Liu, Yunfei Liu, Rui Wen, Delin Kong, Ruxiu Tie, Shanshan Pei, Nan Liu, Pengxu Qian, He Huang, Meng Zhang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Hematology & Oncology
Subjects:
Terminal erythropoiesis
BRD4
CDK9
RhoB
EHMT1/2
Online Access:https://doi.org/10.1186/s13045-025-01721-2
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https://doi.org/10.1186/s13045-025-01721-2

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