MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction

MiR-19-loaded oxidative stress-relief microgels with immunomodulatory and regeneration functions to reduce cardiac remodeling after myocardial infarction

Regeneration therapeutic strategy by microRNAs for boosting cardiomyocyte proliferation in treating myocardial infarction (MI) has the challenges of efficient delivery, and toxicity and risk of sudden death. Herein, oxidative stress-relief microgels were developed for miR-19a/b delivery, modulation...

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Main Authors: Kai Wang, Jun Wen, Wen-Yao Wang, Kefei Zhao, Tong Zhou, Shunqin Wang, Qiaoxuan Wang, Liyin Shen, Yanxin Xiang, Tanchen Ren, Jinghai Chen, Yi-Da Tang, Yang Zhu, Changyou Gao
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Bioactive Materials
Subjects:
Microgels
Cardiomyocyte regeneration
Myocardial infarction
microRNA
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25000520
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http://www.sciencedirect.com/science/article/pii/S2452199X25000520

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