Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation
We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia. Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to requ...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/9480346 |
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| author | Spyridon Fortis Elizabeth R. Lusczek Craig R. Weinert Greg J. Beilman |
| author_facet | Spyridon Fortis Elizabeth R. Lusczek Craig R. Weinert Greg J. Beilman |
| author_sort | Spyridon Fortis |
| collection | DOAJ |
| description | We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia. Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation. We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia. We excluded subjects with history of both COPD and heart failure and patients with obstructive sleep apnea and obstructive lung disease other than COPD. We performed metabolomics analysis using NMR. We constructed partial least squares discriminant analysis (PLS-DA) models to distinguish metabolic profiles. Serum (p=0.001, R2 = 0.397, Q2 = 0.058) and urine metabolic profiles (p<0.001, R2 = 0.419, Q2 = 0.142) were significantly different between the four diagnosis groups by PLS-DA. After excluding stable COPD patients, the metabolomes of the various respiratory failure groups did not cluster separately in serum (p=0.2, R2 = 0.631, Q2 = 0.246) or urine (p=0.065, R2 = 0.602, Q2 = −0.134). However, several metabolites in the serum were reduced in patients with COPD exacerbation and pneumonia. We did not find a metabolic profile unique to COPD exacerbation, but we were able to clearly and reliably distinguish stable COPD patients from patients with respiratory failure in both serum and urine. |
| format | Article |
| id | doaj-art-cebb730f001e48d8b9b1173a2b81ffbf |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-cebb730f001e48d8b9b1173a2b81ffbf2025-02-03T00:58:54ZengWileyCanadian Respiratory Journal1198-22411916-72452017-01-01201710.1155/2017/94803469480346Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure VentilationSpyridon Fortis0Elizabeth R. Lusczek1Craig R. Weinert2Greg J. Beilman3Pulmonary, Department of Medicine, Critical Care and Occupational Medicine, University of Iowa Hospital and Clinics, Iowa City, IA, USACritical Care and Acute Care Surgery Division, Department of Surgery, University of Minnesota, Minneapolis, MN, USAPulmonary and Critical Care Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USACritical Care and Acute Care Surgery Division, Department of Surgery, University of Minnesota, Minneapolis, MN, USAWe aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia. Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation. We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia. We excluded subjects with history of both COPD and heart failure and patients with obstructive sleep apnea and obstructive lung disease other than COPD. We performed metabolomics analysis using NMR. We constructed partial least squares discriminant analysis (PLS-DA) models to distinguish metabolic profiles. Serum (p=0.001, R2 = 0.397, Q2 = 0.058) and urine metabolic profiles (p<0.001, R2 = 0.419, Q2 = 0.142) were significantly different between the four diagnosis groups by PLS-DA. After excluding stable COPD patients, the metabolomes of the various respiratory failure groups did not cluster separately in serum (p=0.2, R2 = 0.631, Q2 = 0.246) or urine (p=0.065, R2 = 0.602, Q2 = −0.134). However, several metabolites in the serum were reduced in patients with COPD exacerbation and pneumonia. We did not find a metabolic profile unique to COPD exacerbation, but we were able to clearly and reliably distinguish stable COPD patients from patients with respiratory failure in both serum and urine.http://dx.doi.org/10.1155/2017/9480346 |
| spellingShingle | Spyridon Fortis Elizabeth R. Lusczek Craig R. Weinert Greg J. Beilman Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation Canadian Respiratory Journal |
| title | Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation |
| title_full | Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation |
| title_fullStr | Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation |
| title_full_unstemmed | Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation |
| title_short | Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation |
| title_sort | metabolomics in copd acute respiratory failure requiring noninvasive positive pressure ventilation |
| url | http://dx.doi.org/10.1155/2017/9480346 |
| work_keys_str_mv | AT spyridonfortis metabolomicsincopdacuterespiratoryfailurerequiringnoninvasivepositivepressureventilation AT elizabethrlusczek metabolomicsincopdacuterespiratoryfailurerequiringnoninvasivepositivepressureventilation AT craigrweinert metabolomicsincopdacuterespiratoryfailurerequiringnoninvasivepositivepressureventilation AT gregjbeilman metabolomicsincopdacuterespiratoryfailurerequiringnoninvasivepositivepressureventilation |