Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis
The clinical presentation of noncystic fibrosis bronchiectasis may be complicated by concomitant conditions, including gastro-oesophageal reflux (GOR). Increased acidic GOR is principally caused by gastro-oesophageal junction incompetence and may arise from lower oesophageal sphincter hypotension, i...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/395020 |
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| author | Annemarie L. Lee Brenda M. Button Linda Denehy John W. Wilson |
| author_facet | Annemarie L. Lee Brenda M. Button Linda Denehy John W. Wilson |
| author_sort | Annemarie L. Lee |
| collection | DOAJ |
| description | The clinical presentation of noncystic fibrosis bronchiectasis may be complicated by concomitant conditions, including gastro-oesophageal reflux (GOR). Increased acidic GOR is principally caused by gastro-oesophageal junction incompetence and may arise from lower oesophageal sphincter hypotension, including transient relaxations, hiatus hernia, and oesophageal dysmotility. Specific pathophysiological features which are characteristic of respiratory diseases including coughing may further increase the risk of GOR in bronchiectasis. Reflux may impact on lung disease severity by two mechanisms, reflex bronchoconstriction and pulmonary microaspiration. Symptomatic and clinically silent reflux has been detected in bronchiectasis, with the prevalence of 26 to 75%. The cause and effect relationship has not been established, but preliminary reports suggest that GOR may influence the severity of bronchiectasis. Further studies examining the implications of GOR in this condition, including its effect across the disease spectrum using a combination of diagnostic tools, will clarify the clinical significance of this comorbidity. |
| format | Article |
| id | doaj-art-ceb5b8e60c0949e68354a8ccdf99396d |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-ceb5b8e60c0949e68354a8ccdf99396d2025-02-03T06:11:00ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/395020395020Gastro-Oesophageal Reflux in Noncystic Fibrosis BronchiectasisAnnemarie L. Lee0Brenda M. Button1Linda Denehy2John W. Wilson3Department of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Physiotherapy, The Alfred Hospital, Commercial Road, Melbourne, VIC 3004, AustraliaDepartment of Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Medicine, Monash University, Melbourne, VIC 3088, AustraliaThe clinical presentation of noncystic fibrosis bronchiectasis may be complicated by concomitant conditions, including gastro-oesophageal reflux (GOR). Increased acidic GOR is principally caused by gastro-oesophageal junction incompetence and may arise from lower oesophageal sphincter hypotension, including transient relaxations, hiatus hernia, and oesophageal dysmotility. Specific pathophysiological features which are characteristic of respiratory diseases including coughing may further increase the risk of GOR in bronchiectasis. Reflux may impact on lung disease severity by two mechanisms, reflex bronchoconstriction and pulmonary microaspiration. Symptomatic and clinically silent reflux has been detected in bronchiectasis, with the prevalence of 26 to 75%. The cause and effect relationship has not been established, but preliminary reports suggest that GOR may influence the severity of bronchiectasis. Further studies examining the implications of GOR in this condition, including its effect across the disease spectrum using a combination of diagnostic tools, will clarify the clinical significance of this comorbidity.http://dx.doi.org/10.1155/2011/395020 |
| spellingShingle | Annemarie L. Lee Brenda M. Button Linda Denehy John W. Wilson Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis Pulmonary Medicine |
| title | Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis |
| title_full | Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis |
| title_fullStr | Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis |
| title_full_unstemmed | Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis |
| title_short | Gastro-Oesophageal Reflux in Noncystic Fibrosis Bronchiectasis |
| title_sort | gastro oesophageal reflux in noncystic fibrosis bronchiectasis |
| url | http://dx.doi.org/10.1155/2011/395020 |
| work_keys_str_mv | AT annemariellee gastrooesophagealrefluxinnoncysticfibrosisbronchiectasis AT brendambutton gastrooesophagealrefluxinnoncysticfibrosisbronchiectasis AT lindadenehy gastrooesophagealrefluxinnoncysticfibrosisbronchiectasis AT johnwwilson gastrooesophagealrefluxinnoncysticfibrosisbronchiectasis |