Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy

Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy

Abstract Eicosanoids are key players in inflammatory diseases and cancer. Targeting their production by inhibiting Group IVA cytosolic phospholipase A2 (cPLA2α) offers a promising approach for cancer therapy. In this study, we synthesize a second generation of thiazolyl ketone inhibitors of cPLA2α s...

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Main Authors: Felicity J. Ashcroft, Asimina Bourboula, Nur Mahammad, Efrosini Barbayianni, Astrid J. Feuerherm, Thanh Thuy Nguyen, Daiki Hayashi, Maroula G. Kokotou, Konstantinos Alevizopoulos, Edward A. Dennis, George Kokotos, Berit Johansen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55536-9
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https://doi.org/10.1038/s41467-024-55536-9

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