Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition

Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition

Background Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1. Patients with MFS are predisposed to aortic aneurysms and dissections, significantly contributing to mortality. Emerging...

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Main Authors: Yuhao Chen, Yuankang Zhu, Xiaoli Ren, Lu Ding, Yubin Xu, Miqi Zhou, Runze Dong, Peifeng Jin, Xiufang Chen, Xiaofang Fan, Ming Li, Yongsheng Gong, Yongyu Wang
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
endothelial cell senescence
fibrillin‐1
induced pluripotent stem cells
Marfan syndrome
TGF‐β
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.037826
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https://www.ahajournals.org/doi/10.1161/JAHA.124.037826

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