The PGAM5–NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis

The PGAM5–NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis

The innate immune sensor NLRP3 inflammasome overactivation is involved in the pathogenesis of ulcerative colitis. PGAM5 is a mitochondrial phosphatase involved in NLRP3 inflammasome activation in macrophages. However, the role of PGAM5 in ulcerative colitis and the mechanisms underlying PGAM5 regula...

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Bibliographic Details
Main Authors: Cheng-Long Gao, Jinqian Song, Haojie Wang, Qinghong Shang, Xin Guan, Gang Xu, Jiayang Wu, Dalei Wu, Yueqin Zheng, Xudong Wu, Feng Zhao, Xindong Liu, Lei Shi, Tao Pang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
PGAM5
APEX2 proximity labeling
Protein–protein interaction
NEK7
NLRP3 inflammasome
Punicalagin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004520
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