Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X

Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X

Abstract DDX3X is an X-linked RNA helicase that escapes X chromosome inactivation and is expressed at higher levels in female brains. Mutations in DDX3X are associated with intellectual disability (ID) and autism spectrum disorder (ASD) and are predominantly identified in females (DDX3X syndrome). U...

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Main Authors: Adele Mossa, Lauren Dierdorff, Jeronimo Lukin, Marta Garcia-Forn, Wei Wang, Fatemeh Mamashli, Yeaji Park, Chiara Fiorenzani, Zeynep Akpinar, Janine Kamps, Jörg Tatzelt, Zhuhao Wu, Silvia De Rubeis
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59680-8
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https://doi.org/10.1038/s41467-025-59680-8

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