Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity
Aim. This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level. Materials and Methods. The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, th...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/239815 |
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| author | Muyesser Sayki Arslan Oya Topaloglu Bekir Ucan Melia Karakose Basak Karbek Esra Tutal Mustafa Caliskan Zeynep Ginis Erman Cakal Mustafa Sahin Mustafa Ozbek Tuncay Delibasi |
| author_facet | Muyesser Sayki Arslan Oya Topaloglu Bekir Ucan Melia Karakose Basak Karbek Esra Tutal Mustafa Caliskan Zeynep Ginis Erman Cakal Mustafa Sahin Mustafa Ozbek Tuncay Delibasi |
| author_sort | Muyesser Sayki Arslan |
| collection | DOAJ |
| description | Aim. This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level. Materials and Methods. The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated. Results. Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant. Conclusions. The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto’s thyroiditis and NTIS. |
| format | Article |
| id | doaj-art-ce5b886b6c764ccc82c2ee47f74b357c |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ce5b886b6c764ccc82c2ee47f74b357c2025-02-03T00:59:56ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/239815239815Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid AutoimmunityMuyesser Sayki Arslan0Oya Topaloglu1Bekir Ucan2Melia Karakose3Basak Karbek4Esra Tutal5Mustafa Caliskan6Zeynep Ginis7Erman Cakal8Mustafa Sahin9Mustafa Ozbek10Tuncay Delibasi11Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Biochemistry, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, School of Medicine, Ankara University, 06230 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, TurkeyAim. This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level. Materials and Methods. The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated. Results. Anti-TPO positivity was significantly more common in those with severe and moderate vitamin D deficiency, as compared to those with a normal 25(OH)D level. Furthermore, TSH levels were significantly lower in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. In addition, there was a significant weak inverse correlation between anti-TPO positivity and the 25(OH)D level and a positive correlation between the TSH level and 25(OH)D level. Only 1 thyroid function test result was compatible with NTIS among the participants with moderate vitamin D deficiency; therefore the difference was not significant. Conclusions. The prevalence of thyroid autoantibody positivity was higher in those with severe and moderate vitamin D deficiency than in those with a normal 25(OH)D level. Additional large-scale studies must be conducted to determine if vitamin D deficiency plays a causal role in the pathogenesis of Hashimoto’s thyroiditis and NTIS.http://dx.doi.org/10.1155/2015/239815 |
| spellingShingle | Muyesser Sayki Arslan Oya Topaloglu Bekir Ucan Melia Karakose Basak Karbek Esra Tutal Mustafa Caliskan Zeynep Ginis Erman Cakal Mustafa Sahin Mustafa Ozbek Tuncay Delibasi Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity The Scientific World Journal |
| title | Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity |
| title_full | Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity |
| title_fullStr | Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity |
| title_full_unstemmed | Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity |
| title_short | Isolated Vitamin D Deficiency Is Not Associated with Nonthyroidal Illness Syndrome, but with Thyroid Autoimmunity |
| title_sort | isolated vitamin d deficiency is not associated with nonthyroidal illness syndrome but with thyroid autoimmunity |
| url | http://dx.doi.org/10.1155/2015/239815 |
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