Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders

Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders

ABSTRACT Despite long-term suppressive antiretroviral therapy (ART), immune dysregulation due to impaired reconstitution of CD4+ T cells is a major hurdle for reducing morbidity and mortality in HIV-1-infected immunological non-responders (INRs, CD4+ T cells ≤350 cells/µL). To evaluate potential imm...

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Bibliographic Details
Main Authors: Ruthu Nagaraju, Pruthvi S. Gowda, Durai M. Gunasekaran, Anita S. Desai, Udaykumar Ranga, Ramesh N. R. Masthi, Manjunatha M. Venkataswamy
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
HIV-1
immunological non-responders
altered CD4+ T-cell subsets
impaired immunological reconstitution
circulatory T follicular helper cells
cTfh
Online Access:https://journals.asm.org/doi/10.1128/mbio.00575-25
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https://journals.asm.org/doi/10.1128/mbio.00575-25

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