Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9

Gastrodin attenuates rheumatoid arthritis by targeting KAT8 to inhibit the lactylation of H3K9

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction, with limited therapeutic options. This study investigated the therapeutic potential of gastrodin (GAS), a natural phenolic glycoside derived from Gastrodia elata, in...

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Main Authors: Yufang Dai, Shunshun Wang, Jiayi Luo, Huiming Yu, Qianqian Du, Shuwan Hou, Minfu Liu, Shan Jiang, Huajiao Xu, Siyi Ye, Muhammad Farrukh Nisar, Haiyan Chen, Jiaqin Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
gastrodin
histone lactylation
KAT8
H3K9
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1559744/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1559744/full

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