Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting Neisseria gonorrhoeae in urine specimens

Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting Neisseria gonorrhoeae in urine specimens

ABSTRACT Nucleic acid amplification testing (NAAT) for N. gonorrhoeae is unavailable in resource-limited settings. We previously developed a CRISPR-based lateral flow assay for detecting N. gonorrhoeae. We aimed to pair that assay with point-of-care DNA extraction, assess performance in clinical uri...

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Main Authors: Lao-Tzu Allan-Blitz, Gordon Adams, Gabriela Sanders, Palak Shah, Krithik Ramesh, Jana Jarolimova, Kevin L. Ard, John A. Branda, Jeffrey D. Klausner, Pardis C. Sabeti, Jacob E. Lemieux
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSphere
Subjects:
Neisseria gonorrhoeae
point of care diagnostic
lateral flow
clinical specimens
CRISPR
Cas13a
Online Access:https://journals.asm.org/doi/10.1128/msphere.00677-24
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https://journals.asm.org/doi/10.1128/msphere.00677-24

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