Elevated plasma trimethyllysine is associated with incident atrial fibrillation
Background/Aim: Trimethyllysine (TML) is a methylated amino acid, which is linked to epigenetic regulation and can serve as a precursor of trimethylamine-N-oxide (TMAO). TMAO is a microbiota-derived metabolite and a potential risk factor of cardiovascular disease. TML has recently been linked to ath...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | American Journal of Preventive Cardiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666667725000054 |
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| author | Mads M Svenningsson Gard FT Svingen Per M Ueland Gerhard Sulo Espen Ø Bjørnestad Eva R Pedersen Indu Dhar Dennis W. Nilsen Ottar Nygård |
| author_facet | Mads M Svenningsson Gard FT Svingen Per M Ueland Gerhard Sulo Espen Ø Bjørnestad Eva R Pedersen Indu Dhar Dennis W. Nilsen Ottar Nygård |
| author_sort | Mads M Svenningsson |
| collection | DOAJ |
| description | Background/Aim: Trimethyllysine (TML) is a methylated amino acid, which is linked to epigenetic regulation and can serve as a precursor of trimethylamine-N-oxide (TMAO). TMAO is a microbiota-derived metabolite and a potential risk factor of cardiovascular disease. TML has recently been linked to atherosclerosis, acute myocardial infarction and prevalent atrial fibrillation (AF). However, any association between circulating TML and incident AF has not yet been reported and was the aim of the current study in a large community based cohort. Methods: Information regarding AF was obtained by linking patient data to national health registries. Risk associations were explored by logistic regression. Potential improvements in risk reclassification were calculated by the continuous net reclassification index (NRI˃0) and the Receiver Operating Curve Area Under the Curve (ROC-AUC). Results: At baseline 3117 patients were included. During a median (25th-75th percentile) follow-up of 10.8 (9.4 – 11.2) years, 492 patients (15.8 %) developed AF. Higher plasma TML was associated with incident AF per 1 SD log-transformed TML (OR (95 % CI) 1.30 (1.16–1.46) P < 0.01). Further analyses also showed an increase in NRI>0 (95 % CI) of 0.24 (0.14–0.33) P < 0.001 and ROC-AUC (95 % CI) of 0.013 (0.004–0.022) P = 0.006. Conclusion: TML was associated with, and improved risk classification of, new-onset AF in this large cohort of community dwelling adults. Our results motivate further studies on the association between TML and cardiac arrhythmias. |
| format | Article |
| id | doaj-art-cdcc2495fadc4102a2f7be69eb2ee25b |
| institution | Kabale University |
| issn | 2666-6677 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj-art-cdcc2495fadc4102a2f7be69eb2ee25b2025-01-23T05:27:49ZengElsevierAmerican Journal of Preventive Cardiology2666-66772025-03-0121100932Elevated plasma trimethyllysine is associated with incident atrial fibrillationMads M Svenningsson0Gard FT Svingen1Per M Ueland2Gerhard Sulo3Espen Ø Bjørnestad4Eva R Pedersen5Indu Dhar6Dennis W. Nilsen7Ottar Nygård8Haukeland University Hospital, Department of Heart Disease, Bergen, Norway; University of Bergen, Department of Clinical Science, Bergen, Norway; Corresponding author at: Haukeland University Hospital, Pb 1400, 5021 Bergen, Norway.Haukeland University Hospital, Department of Heart Disease, Bergen, NorwayBevital AS, Bergen, NorwayUniversity of Bergen, Department of Global Public Health and Primary Care, Bergen, NorwayUniversity of Bergen, Department of Clinical Science, Bergen, Norway; Stavanger University Hospital, Department of Heart Disease, Stavanger, NorwayHaukeland University Hospital, Department of Heart Disease, Bergen, Norway; University of Bergen, Department of Clinical Science, Bergen, NorwayUniversity of Bergen, Department of Clinical Science, Bergen, NorwayUniversity of Bergen, Department of Clinical Science, Bergen, Norway; Stavanger University Hospital, Department of Heart Disease, Stavanger, NorwayHaukeland University Hospital, Department of Heart Disease, Bergen, Norway; University of Bergen, Department of Clinical Science, Bergen, NorwayBackground/Aim: Trimethyllysine (TML) is a methylated amino acid, which is linked to epigenetic regulation and can serve as a precursor of trimethylamine-N-oxide (TMAO). TMAO is a microbiota-derived metabolite and a potential risk factor of cardiovascular disease. TML has recently been linked to atherosclerosis, acute myocardial infarction and prevalent atrial fibrillation (AF). However, any association between circulating TML and incident AF has not yet been reported and was the aim of the current study in a large community based cohort. Methods: Information regarding AF was obtained by linking patient data to national health registries. Risk associations were explored by logistic regression. Potential improvements in risk reclassification were calculated by the continuous net reclassification index (NRI˃0) and the Receiver Operating Curve Area Under the Curve (ROC-AUC). Results: At baseline 3117 patients were included. During a median (25th-75th percentile) follow-up of 10.8 (9.4 – 11.2) years, 492 patients (15.8 %) developed AF. Higher plasma TML was associated with incident AF per 1 SD log-transformed TML (OR (95 % CI) 1.30 (1.16–1.46) P < 0.01). Further analyses also showed an increase in NRI>0 (95 % CI) of 0.24 (0.14–0.33) P < 0.001 and ROC-AUC (95 % CI) of 0.013 (0.004–0.022) P = 0.006. Conclusion: TML was associated with, and improved risk classification of, new-onset AF in this large cohort of community dwelling adults. Our results motivate further studies on the association between TML and cardiac arrhythmias.http://www.sciencedirect.com/science/article/pii/S2666667725000054Atrial fibrillationBiomarkersTrimethyllysine |
| spellingShingle | Mads M Svenningsson Gard FT Svingen Per M Ueland Gerhard Sulo Espen Ø Bjørnestad Eva R Pedersen Indu Dhar Dennis W. Nilsen Ottar Nygård Elevated plasma trimethyllysine is associated with incident atrial fibrillation American Journal of Preventive Cardiology Atrial fibrillation Biomarkers Trimethyllysine |
| title | Elevated plasma trimethyllysine is associated with incident atrial fibrillation |
| title_full | Elevated plasma trimethyllysine is associated with incident atrial fibrillation |
| title_fullStr | Elevated plasma trimethyllysine is associated with incident atrial fibrillation |
| title_full_unstemmed | Elevated plasma trimethyllysine is associated with incident atrial fibrillation |
| title_short | Elevated plasma trimethyllysine is associated with incident atrial fibrillation |
| title_sort | elevated plasma trimethyllysine is associated with incident atrial fibrillation |
| topic | Atrial fibrillation Biomarkers Trimethyllysine |
| url | http://www.sciencedirect.com/science/article/pii/S2666667725000054 |
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