Repigmentation of Tenacious Vitiligo on Apremilast
Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin col...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/2386234 |
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| _version_ | 1832551336742223872 |
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| author | Sara B. Huff Lorie D. Gottwald |
| author_facet | Sara B. Huff Lorie D. Gottwald |
| author_sort | Sara B. Huff |
| collection | DOAJ |
| description | Vitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune problems. Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated. We present the case of a 52-year-old woman with vitiligo for over 2 decades. The patient’s medical history reveals a lack of response to many different approaches. This case highlights the ability of apremilast, an FDA-approved drug for the treatment of psoriasis and psoriatic arthritis, to achieve repigmentation in a case a vitiligo that has been extremely recalcitrant. |
| format | Article |
| id | doaj-art-cdca0def1dc34f02b8c0145889618a6c |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-cdca0def1dc34f02b8c0145889618a6c2025-02-03T06:01:46ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712017-01-01201710.1155/2017/23862342386234Repigmentation of Tenacious Vitiligo on ApremilastSara B. Huff0Lorie D. Gottwald1University of Toledo College of Medicine and Life Sciences, 3000 Arlington Avenue, Toledo, OH 43614, USADepartment of Dermatology, University of Toledo Medical Center, 3000 Arlington Avenue, Toledo, OH 43614, USAVitiligo is a common pigment disorder characterized by acquired loss of function or absence of melanocytes, leading to distinct areas of depigmentation. Physical exam reveals sharply demarcated, depigmented macules or patches on otherwise normal skin. Vitiligo can present at any age, in any skin color. There is no specific serologic marker for diagnosis, but patients often have other autoimmune problems. Treatment options are limited and are difficult given the fact that the pathogenesis of the disease is not well elucidated. We present the case of a 52-year-old woman with vitiligo for over 2 decades. The patient’s medical history reveals a lack of response to many different approaches. This case highlights the ability of apremilast, an FDA-approved drug for the treatment of psoriasis and psoriatic arthritis, to achieve repigmentation in a case a vitiligo that has been extremely recalcitrant.http://dx.doi.org/10.1155/2017/2386234 |
| spellingShingle | Sara B. Huff Lorie D. Gottwald Repigmentation of Tenacious Vitiligo on Apremilast Case Reports in Dermatological Medicine |
| title | Repigmentation of Tenacious Vitiligo on Apremilast |
| title_full | Repigmentation of Tenacious Vitiligo on Apremilast |
| title_fullStr | Repigmentation of Tenacious Vitiligo on Apremilast |
| title_full_unstemmed | Repigmentation of Tenacious Vitiligo on Apremilast |
| title_short | Repigmentation of Tenacious Vitiligo on Apremilast |
| title_sort | repigmentation of tenacious vitiligo on apremilast |
| url | http://dx.doi.org/10.1155/2017/2386234 |
| work_keys_str_mv | AT sarabhuff repigmentationoftenaciousvitiligoonapremilast AT loriedgottwald repigmentationoftenaciousvitiligoonapremilast |