A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery
Disruption of cholinesterases and, as a consequence, increased levels of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of th...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2025-01-01
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| Series: | Beilstein Journal of Nanotechnology |
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| Online Access: | https://doi.org/10.3762/bjnano.16.2 |
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| author | Elina E. Mansurova Andrey A. Maslennikov Anna P. Lyubina Alexandra D. Voloshina Irek R. Nizameev Marsil K. Kadirov Anzhela A. Mikhailova Polina V. Mikshina Albina Y. Ziganshina Igor S. Antipin |
| author_facet | Elina E. Mansurova Andrey A. Maslennikov Anna P. Lyubina Alexandra D. Voloshina Irek R. Nizameev Marsil K. Kadirov Anzhela A. Mikhailova Polina V. Mikshina Albina Y. Ziganshina Igor S. Antipin |
| author_sort | Elina E. Mansurova |
| collection | DOAJ |
| description | Disruption of cholinesterases and, as a consequence, increased levels of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of this is often difficult. One promising solution may be the development of antidote delivery systems that will release the drug only when acetylcholine levels are elevated. This approach will ensure timely delivery of the antidote and minimize side effects associated with uncontrolled drug release. Here, we describe the creation of a new smart system that serves as a carrier for delivering an antidote (i.e., atropine) and functions as a synthetic esterase to hydrolyze acetylcholine. The nanocarrier was synthesized through microemulsion polycondensation of phenylboronic acid with resorcinarenes containing hydroxy, imidazole, and carboxylic groups on the upper rim. The nanocarrier breaks down acetylcholine into choline and acetic acid. The latter acts on the boronate bonds, dissociating them. This leads to the destruction of the nanocarrier and the release of the antidote. The paper covers the creation of the nanocarrier, its physicochemical and biological properties, encapsulation of the antidote, acetylcholine hydrolysis, and antidote release. |
| format | Article |
| id | doaj-art-cdc9aba4710d44f78b4a4dc34332a1c2 |
| institution | Kabale University |
| issn | 2190-4286 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj-art-cdc9aba4710d44f78b4a4dc34332a1c22025-02-03T09:10:11ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862025-01-01161112410.3762/bjnano.16.22190-4286-16-2A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine deliveryElina E. Mansurova0Andrey A. Maslennikov1Anna P. Lyubina2Alexandra D. Voloshina3Irek R. Nizameev4Marsil K. Kadirov5Anzhela A. Mikhailova6Polina V. Mikshina7Albina Y. Ziganshina8Igor S. Antipin9A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Centre, Russian Academy of Sciences, Arbuzov str. 8, Kazan 420088, Russia Alexander Butlerov Institute of Chemistry, Kazan Federal University, Lobachevsky str. 1/29, Kazan 420008, Russia A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Centre, Russian Academy of Sciences, Arbuzov str. 8, Kazan 420088, Russia A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Centre, Russian Academy of Sciences, Arbuzov str. 8, Kazan 420088, Russia Kazan National Research Technical University named after A.N. Tupolev - KAI, 10, K. Marx str., Kazan 420111, Russia A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Centre, Russian Academy of Sciences, Arbuzov str. 8, Kazan 420088, Russia Kazan Institute of Biochemistry and Biophysics FRC Kazan Scientific Centre, Russian Academy of Sciences, Lobachevsky str. 2, Kazan 420111, Russia Kazan Institute of Biochemistry and Biophysics FRC Kazan Scientific Centre, Russian Academy of Sciences, Lobachevsky str. 2, Kazan 420111, Russia A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Centre, Russian Academy of Sciences, Arbuzov str. 8, Kazan 420088, Russia Alexander Butlerov Institute of Chemistry, Kazan Federal University, Lobachevsky str. 1/29, Kazan 420008, Russia Disruption of cholinesterases and, as a consequence, increased levels of acetylcholine lead to serious disturbances in the functioning of the nervous system, including death. The need for rapid administration of an antidote to restore esterase activity is critical, but practical implementation of this is often difficult. One promising solution may be the development of antidote delivery systems that will release the drug only when acetylcholine levels are elevated. This approach will ensure timely delivery of the antidote and minimize side effects associated with uncontrolled drug release. Here, we describe the creation of a new smart system that serves as a carrier for delivering an antidote (i.e., atropine) and functions as a synthetic esterase to hydrolyze acetylcholine. The nanocarrier was synthesized through microemulsion polycondensation of phenylboronic acid with resorcinarenes containing hydroxy, imidazole, and carboxylic groups on the upper rim. The nanocarrier breaks down acetylcholine into choline and acetic acid. The latter acts on the boronate bonds, dissociating them. This leads to the destruction of the nanocarrier and the release of the antidote. The paper covers the creation of the nanocarrier, its physicochemical and biological properties, encapsulation of the antidote, acetylcholine hydrolysis, and antidote release.https://doi.org/10.3762/bjnano.16.2acetylcholineantidote deliveryartificial cholinesteraseatropinenanocarrierresorcinarene |
| spellingShingle | Elina E. Mansurova Andrey A. Maslennikov Anna P. Lyubina Alexandra D. Voloshina Irek R. Nizameev Marsil K. Kadirov Anzhela A. Mikhailova Polina V. Mikshina Albina Y. Ziganshina Igor S. Antipin A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery Beilstein Journal of Nanotechnology acetylcholine antidote delivery artificial cholinesterase atropine nanocarrier resorcinarene |
| title | A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery |
| title_full | A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery |
| title_fullStr | A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery |
| title_full_unstemmed | A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery |
| title_short | A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery |
| title_sort | nanocarrier containing carboxylic and histamine groups with dual action acetylcholine hydrolysis and antidote atropine delivery |
| topic | acetylcholine antidote delivery artificial cholinesterase atropine nanocarrier resorcinarene |
| url | https://doi.org/10.3762/bjnano.16.2 |
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