Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application
pH sensitivity of chitosan allows for precise phase transitions in acidic environments, controlling swelling and shrinking, making chitosan suitable for drug delivery systems. pH transitions are modulated by the presence of cross-linkers by the functionalization of the chitosan chain. This review re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/2/252 |
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| author | Yaride Pérez-Pacheco Bartosz Tylkowski Ricard García-Valls |
| author_facet | Yaride Pérez-Pacheco Bartosz Tylkowski Ricard García-Valls |
| author_sort | Yaride Pérez-Pacheco |
| collection | DOAJ |
| description | pH sensitivity of chitosan allows for precise phase transitions in acidic environments, controlling swelling and shrinking, making chitosan suitable for drug delivery systems. pH transitions are modulated by the presence of cross-linkers by the functionalization of the chitosan chain. This review relays a summary of chitosan functionalization and tailoring to optimize drug release. The potential to customize chitosan for different environments and therapeutic uses introduces opportunities for drug encapsulation and release. The focus on improving drug encapsulation and sustained release in specific tissues is an advanced interpretation, reflecting the evolving role of chitosan in achieving targeted and more efficient therapeutic outcomes. This review describes strategies to improve solubility and stability and ensure the controlled release of encapsulated drugs. The discussion on optimizing factors like cross-linking density, particle size, and pH for controlled drug release introduces a deeper understanding of how to achieve specific therapeutic effects. These strategies represent a refined approach to designing chitosan-based systems, pushing the boundaries of sustained release technologies and offering new avenues for precise drug delivery profiles. |
| format | Article |
| id | doaj-art-cdaef546b7b643f18057f58b80098e46 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-cdaef546b7b643f18057f58b80098e462025-01-24T13:43:16ZengMDPI AGMolecules1420-30492025-01-0130225210.3390/molecules30020252Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic ApplicationYaride Pérez-Pacheco0Bartosz Tylkowski1Ricard García-Valls2Department of Chemical Engineering, Universitat Rovira i Virgili, Av. Països Catalans 26, Campus Sescelades, 43007 Tarragona, SpainDepartment of Chemical Engineering, Universitat Rovira i Virgili, Av. Països Catalans 26, Campus Sescelades, 43007 Tarragona, SpainDepartment of Chemical Engineering, Universitat Rovira i Virgili, Av. Països Catalans 26, Campus Sescelades, 43007 Tarragona, SpainpH sensitivity of chitosan allows for precise phase transitions in acidic environments, controlling swelling and shrinking, making chitosan suitable for drug delivery systems. pH transitions are modulated by the presence of cross-linkers by the functionalization of the chitosan chain. This review relays a summary of chitosan functionalization and tailoring to optimize drug release. The potential to customize chitosan for different environments and therapeutic uses introduces opportunities for drug encapsulation and release. The focus on improving drug encapsulation and sustained release in specific tissues is an advanced interpretation, reflecting the evolving role of chitosan in achieving targeted and more efficient therapeutic outcomes. This review describes strategies to improve solubility and stability and ensure the controlled release of encapsulated drugs. The discussion on optimizing factors like cross-linking density, particle size, and pH for controlled drug release introduces a deeper understanding of how to achieve specific therapeutic effects. These strategies represent a refined approach to designing chitosan-based systems, pushing the boundaries of sustained release technologies and offering new avenues for precise drug delivery profiles.https://www.mdpi.com/1420-3049/30/2/252chitosanchitosan derivativeschitosan capsules |
| spellingShingle | Yaride Pérez-Pacheco Bartosz Tylkowski Ricard García-Valls Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application Molecules chitosan chitosan derivatives chitosan capsules |
| title | Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application |
| title_full | Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application |
| title_fullStr | Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application |
| title_full_unstemmed | Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application |
| title_short | Chitosan Micro/Nanocapsules in Action: Linking Design, Production, and Therapeutic Application |
| title_sort | chitosan micro nanocapsules in action linking design production and therapeutic application |
| topic | chitosan chitosan derivatives chitosan capsules |
| url | https://www.mdpi.com/1420-3049/30/2/252 |
| work_keys_str_mv | AT yarideperezpacheco chitosanmicronanocapsulesinactionlinkingdesignproductionandtherapeuticapplication AT bartosztylkowski chitosanmicronanocapsulesinactionlinkingdesignproductionandtherapeuticapplication AT ricardgarciavalls chitosanmicronanocapsulesinactionlinkingdesignproductionandtherapeuticapplication |