Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis
Common metastasis sites for cervical cancer are the lungs, bones, liver, brain, ovaries, and lymph nodes, among other sites. Skin metastasis is very uncommon, and is only observed in approximately 1% of patients. The cancer spreads typically through lymphatic or blood vessels, but a definitive examp...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1528957/full |
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| author | Liwen Guo Yanqiong Liu Shuhua Zhang Wei Liu Wei Liu |
| author_facet | Liwen Guo Yanqiong Liu Shuhua Zhang Wei Liu Wei Liu |
| author_sort | Liwen Guo |
| collection | DOAJ |
| description | Common metastasis sites for cervical cancer are the lungs, bones, liver, brain, ovaries, and lymph nodes, among other sites. Skin metastasis is very uncommon, and is only observed in approximately 1% of patients. The cancer spreads typically through lymphatic or blood vessels, but a definitive example of lymphatic spread has not been documented thoroughly in the existing literature. Cutaneous metastasis may be confused with cellulitis or a rash; hence, an immediate cutaneous biopsy of any suspicious lesions is recommended. There is no consensus regarding the treatment of this condition. Only one documented case has shown that a combination of paclitaxel, carboplatin, bevacizumab, and zoledronic acid can lead to a complete metabolic response. Our study, which used two cycles of albumin-bound paclitaxel, cisplatin, and bevacizumab, followed by four cycles of the same regimen plus terprelimab for metastases with CPS scores of Programmed death-ligand 1 (PD-L1) over 10, resulted in a stable complete response for over eight months. Our contribution may assist in formulating effective treatment guidelines for the cutaneous metastasis of squamous cervical carcinoma in the future. |
| format | Article |
| id | doaj-art-cd92a3f795034943a17cb9f231d6b4e4 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-cd92a3f795034943a17cb9f231d6b4e42025-01-20T09:40:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15289571528957Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosisLiwen Guo0Yanqiong Liu1Shuhua Zhang2Wei Liu3Wei Liu4Hunan Cancer Hospital, The Affiliated Cancer Hospital of the Xiangya School of Medicine, Central South University, Changsha, ChinaHunan Cancer Hospital, The Affiliated Cancer Hospital of the Xiangya School of Medicine, Central South University, Changsha, ChinaThird Xiangya Hospital, Central South University, Changsha, ChinaHunan Cancer Hospital, The Affiliated Cancer Hospital of the Xiangya School of Medicine, Central South University, Changsha, ChinaPostdoctor of Pathology of Second Xiangya Hospital, Changsha, China; Honored Professor of Pathology of Shaodong People’s Hospital, Shaodong, Hunan ProvinceCommon metastasis sites for cervical cancer are the lungs, bones, liver, brain, ovaries, and lymph nodes, among other sites. Skin metastasis is very uncommon, and is only observed in approximately 1% of patients. The cancer spreads typically through lymphatic or blood vessels, but a definitive example of lymphatic spread has not been documented thoroughly in the existing literature. Cutaneous metastasis may be confused with cellulitis or a rash; hence, an immediate cutaneous biopsy of any suspicious lesions is recommended. There is no consensus regarding the treatment of this condition. Only one documented case has shown that a combination of paclitaxel, carboplatin, bevacizumab, and zoledronic acid can lead to a complete metabolic response. Our study, which used two cycles of albumin-bound paclitaxel, cisplatin, and bevacizumab, followed by four cycles of the same regimen plus terprelimab for metastases with CPS scores of Programmed death-ligand 1 (PD-L1) over 10, resulted in a stable complete response for over eight months. Our contribution may assist in formulating effective treatment guidelines for the cutaneous metastasis of squamous cervical carcinoma in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1528957/fullcutaneous metastasiscervical carcinomaprognosiscomplete responseimmunochemotherapymolecular diagnosis |
| spellingShingle | Liwen Guo Yanqiong Liu Shuhua Zhang Wei Liu Wei Liu Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis Frontiers in Immunology cutaneous metastasis cervical carcinoma prognosis complete response immunochemotherapy molecular diagnosis |
| title | Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis |
| title_full | Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis |
| title_fullStr | Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis |
| title_full_unstemmed | Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis |
| title_short | Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis |
| title_sort | case report cutaneous metastasis of squamous cervical carcinoma complete regression after molecular diagnosis |
| topic | cutaneous metastasis cervical carcinoma prognosis complete response immunochemotherapy molecular diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1528957/full |
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